Protective effects of apocynin against ionizing radiation-induced hepatotoxicity in rats

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dc.authoridVardı, Nigar/0000-0003-0576-1696
dc.authoridParlakpınar, Hakan/0000-0001-9497-3468
dc.authoridParlakpinar, Hakan/0000-0001-9497-3468
dc.authoridCagin, Yasir Furkan/0000-0002-2538-857X
dc.authorwosidVardı, Nigar/C-9549-2018
dc.authorwosidParlakpınar, Hakan/T-6517-2018
dc.authorwosidParlakpinar, Hakan/V-6637-2019
dc.authorwosidCagin, Yasir Furkan/ABI-2709-2020
dc.contributor.authorCagin, Yasir Furkan
dc.contributor.authorParlakpinar, Hakan
dc.contributor.authorVardi, Nigar
dc.contributor.authorAksanyar, Salih
dc.date.accessioned2024-08-04T20:50:18Z
dc.date.available2024-08-04T20:50:18Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractRadiation hepatotoxicity is thought to be due to free oxygen radicals. We investigated the protective effects of apocynin (APO) against ionizing radiation induced oxidative stress in liver tissue following whole body ionizing radiation. We divided rats into four groups. The control group was injected intraperitoneally (i.p.) with saline for five consecutive days. A second group was injected i.p. with saline for 5 days and after 24 h, a single-dose of radiation (800 cGy) was administered to the whole abdomen. A third group was injected i.p. with 20 mg/kg APO for 5 days. A fourth group was injected i.p. with APO for 5 days and after 24 h, the rats were exposed to radiation. Ionizing radiation induced hepatotoxicity was demonstrated biochemically by significant changes in oxidative and antioxidant parameters. Our findings suggest that APO treatment may be protective against radiation induced hepatic injury by decreasing oxidative stress and increasing antioxidant activity.en_US
dc.identifier.doi10.1080/10520295.2021.1936641
dc.identifier.endpage235en_US
dc.identifier.issn1052-0295
dc.identifier.issn1473-7760
dc.identifier.issue3en_US
dc.identifier.pmid34120545en_US
dc.identifier.scopus2-s2.0-85107814537en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage228en_US
dc.identifier.urihttps://doi.org/10.1080/10520295.2021.1936641
dc.identifier.urihttps://hdl.handle.net/11616/99984
dc.identifier.volume97en_US
dc.identifier.wosWOS:000661309100001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofBiotechnic & Histochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectApocyninen_US
dc.subjecthepatotoxicityen_US
dc.subjectliveren_US
dc.subjectoxidative stressen_US
dc.subjectradiationen_US
dc.subjectratsen_US
dc.titleProtective effects of apocynin against ionizing radiation-induced hepatotoxicity in ratsen_US
dc.typeArticleen_US

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