Therapeutic effects of cinnamon bark oil on sciatic nerve injury in rats

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dc.authoridColak, Mehmet/0000-0003-0896-4990
dc.authoridParlakpınar, Hakan/0000-0001-9497-3468
dc.authoridOzhan, Onural/0000-0001-9018-7849
dc.authorwosidColak, Mehmet/JBS-4883-2023
dc.authorwosidParlakpınar, Hakan/T-6517-2018
dc.authorwosidOzhan, Onural/AAE-2356-2020
dc.contributor.authorOzhan, O.
dc.contributor.authorIzci, S. F.
dc.contributor.authorHuz, M.
dc.contributor.authorColak, M.
dc.contributor.authorKucukakcali, Z.
dc.contributor.authorParlakpinar, H.
dc.date.accessioned2024-08-04T20:54:29Z
dc.date.available2024-08-04T20:54:29Z
dc.date.issued2023
dc.departmentİnönü Üniversitesien_US
dc.description.abstract- OBJECTIVE: The aim of this study was to investigate the effects of cinnamon bark essential oil (CBO) on analgesia, motor activity, balance, and coordination in rats with sciatic nerve damage. MATERIALS AND METHODS: Rats were divided into three groups as simply randomized. The right sciatic nerve (RSN) of the Sham group was explored. Only vehicle solution was applied for 28 days. The RSN of the sciatic nerve injury (SNI) group was explored. Damage was created by unilateral clamping, and vehicle solution was applied for 28 days. The RSN of the sciatic nerve injury+cinnamon bark essential oil (SNI+CBO) group was explored. SNI was created by unilateral clamping and CBO was applied for 28 days. In the experiment study, motor activity, balance, and coordination measurements were made with rotarod and accelerod tests. A hot plate test was performed for analgesia measurements. Histopathology studies were carried out with the sciatic nerve tissues.RESULTS: In the rotarod test, there was a statistically significant difference between the SNI group and the SNI+CBO group (p<0.05). According to the accelerod test findings, there was a statistically significant difference between the SNI group with the Sham and SNI+CBO groups. In the hot plate test, there was a statistically significant difference between the SNI group with the Sham and SNI+CBO groups (p<0.05). In comparison to the Sham group and the SNI group, the SNI+CBO group was shown to have the greatest expression level of vimentin.CONCLUSIONS: We have concluded that CBO can be used as an adjuvant treatment in cases of SNI, increased pain, nociception, impaired balance, motor activity, and coordination. Our results will be supported by further studies.en_US
dc.description.sponsorshipScientific and Technological Research Council of Tuuml;rki-ye [1919B012002540]en_US
dc.description.sponsorshipFunding This research is supported by a research grant from the Scientific and Technological Research Council of Turki-ye (Project number: 1919B012002540 belongs to S.F. Izci) .en_US
dc.identifier.endpage5853en_US
dc.identifier.issn1128-3602
dc.identifier.issue12en_US
dc.identifier.pmid37401321en_US
dc.identifier.scopus2-s2.0-85163971661en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage5841en_US
dc.identifier.urihttps://hdl.handle.net/11616/101447
dc.identifier.volume27en_US
dc.identifier.wosWOS:001036880000023en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherVerduci Publisheren_US
dc.relation.ispartofEuropean Review For Medical and Pharmacological Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject& nbspen_US
dc.subjectnerve injuryen_US
dc.subjectCinnamon bark oilen_US
dc.subjectMotor ac-tivityen_US
dc.subjectAnalgesiaen_US
dc.subjectVimentinen_US
dc.titleTherapeutic effects of cinnamon bark oil on sciatic nerve injury in ratsen_US
dc.typeArticleen_US

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