Synthesis, Antibacterial and Antifungal Activities of New Bis-5(6)-nitrobenzimidazoles

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dc.authoridGünal, Selami/0000-0002-4752-5176
dc.authoridKUCUKBAY, HASAN/0000-0002-7180-9486
dc.authoridDURMAZ, RIZA/0000-0001-6561-778X
dc.authorwosidGünal, Selami/AAA-7246-2021
dc.authorwosidKUCUKBAY, HASAN/A-5050-2019
dc.authorwosidDURMAZ, Rıza/HJH-4918-2023
dc.contributor.authorKucukbay, Hasan
dc.contributor.authorDurmaz, Riza
dc.contributor.authorSireci, Nihat
dc.contributor.authorGunal, Selami
dc.date.accessioned2024-08-04T20:32:26Z
dc.date.available2024-08-04T20:32:26Z
dc.date.issued2010
dc.departmentİnönü Üniversitesien_US
dc.description.abstractSeventeen bis-5(6)-nitrobenzimidazole compounds and their salt derivatives were synthesized from the reaction of 5(6)-nitrobenzimidazole and appropriate alkyl dihalides and alkyl halides. The synthesized compounds were identified by (1)H, (13)C NMR, FT-TR spectroscopic techniques and elemental analysis. All compounds studied in this work were screened for their in vitro antimicrobial activitiy against the standard strains such as Staphylococcus aureus ATCC 29213, Enterococcus faecalis ATCC 29212, Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 27853 and the yeasts Candida albicans and Candida tropicalis. Ten of the compounds were found effective to inhibit the growth of gram positive (E.faecalis and S. aureus) at MIC values between 50-400 mu g/mL. Seven of the compounds exhibit antimicrobial activity against gram negative bactreria (E. coli and P aeruginosa) at the concentrations studied (50-400 mu g/mL). Nearly all compounds tested in this work showed antifungal activity with a range of the MICs between 50 and 800 mu g/mL.en_US
dc.description.sponsorshipInonu Universty [BAPB-2007/46]en_US
dc.description.sponsorshipThe authors wish to thank Inonu Universty Research Fund (BAPB-2007/46 and 2008-05 Directed projects) for financial support of this study.en_US
dc.identifier.endpage2824en_US
dc.identifier.issn0970-7077
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-77954419781en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage2816en_US
dc.identifier.urihttps://hdl.handle.net/11616/95076
dc.identifier.volume22en_US
dc.identifier.wosWOS:000274581800051en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherAsian Journal Of Chemistryen_US
dc.relation.ispartofAsian Journal of Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject5(6)-Nitrobenzimidazoleen_US
dc.subjectBis-benzimidazolesen_US
dc.subjectAntibacterial activitiyen_US
dc.subjectAntifungal activitiyen_US
dc.subjectin vitro studiesen_US
dc.subjectSynthesisen_US
dc.titleSynthesis, Antibacterial and Antifungal Activities of New Bis-5(6)-nitrobenzimidazolesen_US
dc.typeArticleen_US

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