Molecular epidemiology of methicillin-resistant Staphylococcus aureus isolates from clinical specimens of patients with nosocomial infection: Are there unnoticed silent outbreaks?

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dc.authorscopusid6602248295
dc.authorscopusid57213650668
dc.authorscopusid6602612326
dc.authorscopusid13105327500
dc.authorscopusid13004585100
dc.authorscopusid57195695569
dc.contributor.authorTekerekoglu M.S.
dc.contributor.authorAy S.
dc.contributor.authorOtlu B.
dc.contributor.authorÇiçek A.
dc.contributor.authorKayabaş Ü.
dc.contributor.authorDurmaz R.
dc.date.accessioned2024-08-04T20:00:48Z
dc.date.available2024-08-04T20:00:48Z
dc.date.issued2007
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBacteriological and epidemiological studies were carried out on 90 isolates of methicillin-resistant Staphylococcus aureus (MRSA) at lurgut Özal Medical Center of Inönü University, (Malatya/Turkey). MRSA isolates were obtained from patients with nosocomial infections. Staphylococcus aureus clinical isolates were collected between May 2004-May 2005. Isolates were tested for resistance to methicillin. Antimicrobial susceptibility testing and slime production evaluation was performed. Genotype studies were carried out by arbitrarily primed polymerase chain reaction (AP-PCR) and consequent cluster analysis. All of the isolates were mecA-positive in a PCR-based assay; all exhibited resistance to oxacillin, by agar dilution (MICs ?4mg/L) and disc diffusion methods, and multiple antibiotics. Most MRSA isolates were collected in intensive care units. Of 90 samples, 53 were found to be unrelated to the others while the remaining 37 strains were either identical or closely related. Dendrogram analysis identified nine major clusters. These data support the opinion that MRSA are significant nosocomial pathogens in intensive care units and that resistant clones may be transmitted between patients. Molecular epidemiological tools are helpful for understanding transmission patterns and sources of infection, and are useful for measuring outcomes of intervention strategies implemented to reduce nosocomial MRSA.en_US
dc.identifier.endpage137en_US
dc.identifier.issn1121-7138
dc.identifier.issue2en_US
dc.identifier.pmid17619257en_US
dc.identifier.scopus2-s2.0-34250881607en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage131en_US
dc.identifier.urihttps://hdl.handle.net/11616/91015
dc.identifier.volume30en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofNew Microbiologicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMethicillin-resistant Staphylococcus aureusen_US
dc.subjectMolecular typingen_US
dc.subjectNosocomial infectionen_US
dc.titleMolecular epidemiology of methicillin-resistant Staphylococcus aureus isolates from clinical specimens of patients with nosocomial infection: Are there unnoticed silent outbreaks?en_US
dc.typeArticleen_US

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