Beneficial role of aminoguanidine on acute cardiomyopathy related to doxorubicin-treatment

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dc.authoridAcet, Ahmet/0000-0003-1131-1878
dc.authoridParlakpınar, Hakan/0000-0001-9497-3468
dc.authoridPolat, Alaadin/0000-0002-6920-3856
dc.authoridÇOLAK, CEMİL/0000-0001-5406-098X
dc.authoridCigremis, Yilmaz/0000-0002-8600-0946
dc.authoridParlakpinar, Hakan/0000-0001-9497-3468
dc.authoridPolat, Alaadin/0000-0002-6920-3856
dc.authorwosidAcet, Ahmet/AAB-3273-2021
dc.authorwosidParlakpınar, Hakan/T-6517-2018
dc.authorwosidOzturk, Feral/A-2678-2016
dc.authorwosidPolat, Alaadin/Q-4052-2018
dc.authorwosidÇOLAK, CEMİL/ABI-3261-2020
dc.authorwosidErmis, Necip/HJP-7061-2023
dc.authorwosidCigremis, Yilmaz/O-6019-2015
dc.contributor.authorCigremis, Yilmaz
dc.contributor.authorParlakpinar, Hakan
dc.contributor.authorPolat, Alaadin
dc.contributor.authorColak, Cemil
dc.contributor.authorOzturk, Feral
dc.contributor.authorSahna, Engin
dc.contributor.authorErmis, Necip
dc.date.accessioned2024-08-04T20:15:24Z
dc.date.available2024-08-04T20:15:24Z
dc.date.issued2006
dc.departmentİnönü Üniversitesien_US
dc.description.abstractDoxorubicin (DOX) is a broad-spectrum anthracycline antibiotic that has cardiotoxicity as a major side effect. One mechanism of this toxicity is believed to involve the reactive oxygen radical species (ROS); these agents likely account for the pathophysiology of DOX-induced cardiomyopathy. Aminoguanidine (AG) is an effective antioxidant and free radical scavenger which has long been known to protect against ROS formation. We investigated the effects of AG on DOX-induced changes in thiobarbituric acid reactive substances (TBARS) and reduced glutathione (GSH) content. The rats were divided into four groups:1) Control; 2) DOX group; injected intraperitoneally (i.p.) with DOX 20 mg/kg in a single dose 3) AG-treated group; injected i.p. in single dose of 20 mg/kg DOX plus 100 mg/kg AG 1 h before the DOX for 3 days, 4) AG group; injected i.p. with AG 100 mg/kg for 3 days. DOX administration to control rats increased TBARS and decreased GSH levels. AG administration before DOX injection caused significant decrease in TBARS and increase in GSH levels in the heart tissue when compared with DOX only. Morphological changes, including severe myocardial fibrosis and inflammatory cell infiltration were clearly observed in the DOX-treated heart. AG reversed the DOX-induced heart damage. Therefore AG could protect the heart tissue against free radical injury. The application of AG during cancer chemotherapy may attenuate tissue damage and improve the therapeutic index of DOX.en_US
dc.identifier.doi10.1007/s11010-005-9072-8
dc.identifier.endpage154en_US
dc.identifier.issn0300-8177
dc.identifier.issn1573-4919
dc.identifier.issue1-2en_US
dc.identifier.pmid16612575en_US
dc.identifier.scopus2-s2.0-33646123097en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage149en_US
dc.identifier.urihttps://doi.org/10.1007/s11010-005-9072-8
dc.identifier.urihttps://hdl.handle.net/11616/94370
dc.identifier.volume285en_US
dc.identifier.wosWOS:000238521100015en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofMolecular and Cellular Biochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectaminoguanidineen_US
dc.subjectcardiomyopathyen_US
dc.subjectdoxorubicinen_US
dc.subjectthiobarbituric acid reactive substancesen_US
dc.titleBeneficial role of aminoguanidine on acute cardiomyopathy related to doxorubicin-treatmenten_US
dc.typeArticleen_US

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