Protective effects of ascorbic acid on hepatotoxicity and oxidative stress caused by carbon tetrachloride in the liver of Wistar rats

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dc.authoridAteş, Burhan/0000-0001-6080-229X
dc.authoridTaşlidere, Aslı Cetin/0000-0003-3902-3210
dc.authoridGül, Mehmet/0000-0002-1374-0783;
dc.authorwosidAteş, Burhan/AAA-3730-2021
dc.authorwosidTaşlidere, Aslı Cetin/AAB-3979-2021
dc.authorwosidGül, Mehmet/ABI-6336-2020
dc.authorwosidOzturk, Feral/A-2678-2016
dc.contributor.authorOzturk, Ismail Cetin
dc.contributor.authorOzturk, Feral
dc.contributor.authorGul, Mehmet
dc.contributor.authorAtes, Burhan
dc.contributor.authorCetin, Asli
dc.date.accessioned2024-08-04T20:31:19Z
dc.date.available2024-08-04T20:31:19Z
dc.date.issued2009
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThis study was planned to investigate the protective effect of L(+)-ascorbic acid (Vit C) on CCl4-induced hepatotoxicity and oxidative stress in the liver of Wistar rats (Rattus Norvegicus, strain Wistar). Twenty-four adult male Wistar rats were fed with standard rat chow diet for 10 days and randomly were divided into four groups of six each as follows: (1) control, (2) CCl4, (3) CCl4 + Vit C, (4) Vit C groups. CCl4 was applied to rats belonging to CCl4 and CCl4 + Vit C groups Subcutaneously at 1 mg ka(-1) dose CCl4 for 3 days. Vit C applied to CCl4 + Vit C and Vit C group rats intraperitoneally at 300 mg kg(-1) dose for 3 days. All rats were sacrificed and livers were quickly removed on the fourth day of the experiment. MDA, total glutathione (T.GSH) levels and superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-PX) activities were measured in the liver of all groups of rats and also serum alanine amino transferase (ALT) and aspartate amino transferase (AST) activities were detected to determine liver functions in all groups of rats. Histopathological changes were evaluated by light and transmission electron microscopes. In CCl4 + Vit C group, MDA level was significantly decreased (p < 0.05) and SOD, CAT, GSH-PX activities were significantly increased (p < 0.005, 0.01, 0.05) respectively, T.GSH level was significantly increased (p < 0.005) and serum ALT and AST activities were significantly decreased (p < 0.01, 0.05), respectively, when compared with CCl4 group. These results show that Vit C has a highly protective effect on hepatotoxicity and oxidative stress caused by CCl4. Copyright (C) 2009 John Wiley & Sons, Ltd.en_US
dc.identifier.doi10.1002/cbf.1575
dc.identifier.endpage315en_US
dc.identifier.issn0263-6484
dc.identifier.issn1099-0844
dc.identifier.issue5en_US
dc.identifier.pmid19548269en_US
dc.identifier.scopus2-s2.0-70349232969en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage309en_US
dc.identifier.urihttps://doi.org/10.1002/cbf.1575
dc.identifier.urihttps://hdl.handle.net/11616/94874
dc.identifier.volume27en_US
dc.identifier.wosWOS:000268520700008en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWiley-Blackwellen_US
dc.relation.ispartofCell Biochemistry and Functionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectcarbon tetrachlorideen_US
dc.subjectascorbic aciden_US
dc.subjecthepatotoxicityen_US
dc.subjectoxidative stressen_US
dc.subjectultrastructureen_US
dc.titleProtective effects of ascorbic acid on hepatotoxicity and oxidative stress caused by carbon tetrachloride in the liver of Wistar ratsen_US
dc.typeArticleen_US

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