Effects of caffeic acid phenethyl ester (CAPE) on sepsis in rats

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dc.authoridDinçkan, Ayhan/0000-0003-1395-333X
dc.authoridAteş, Burhan/0000-0001-6080-229X
dc.authorwosidDinçkan, Ayhan/AAO-2633-2020
dc.authorwosidAteş, Burhan/AAA-3730-2021
dc.contributor.authorTekin, Ahmet
dc.contributor.authorKucukkartallar, Tevfik
dc.contributor.authorTurkyilmaz, Serdar
dc.contributor.authorDinckan, Ayhan
dc.contributor.authorEsen, Hasan
dc.contributor.authorAtes, Burhan
dc.contributor.authorYilmaz, Huseyin
dc.date.accessioned2024-08-04T20:30:54Z
dc.date.available2024-08-04T20:30:54Z
dc.date.issued2008
dc.departmentİnönü Üniversitesien_US
dc.description.abstractSepsis is still a major cause of the high mortality rate in the intensive care unit. Many studies have been published about the severity of sepsis, but the cause of mortality in sepsis and multiorgan failure is still obscure. This study investigated the effects of caffeic acid phenethyl ester (CAPE) particularly on the inflammatory and related histopathological changes in the lung, liver and kidney in an experimental sepsis model. Forty Sprague Dawley rats were used in this study, and were divided into four groups of ten rats each, as follows: Group I was given intraperitoneal saline infusion treatment. Group II was given intraperitoneal CAPE infusion treatment. Sepsis was induced in the animals in Group III (sepsis with saline infusion), while Group IV rats underwent induced sepsis plus CAPE infusion treatment (sepsis with CAPE infusion). Sampling was performed 48 h after treatment. The induction of sepsis resulted in a significant increase in serum glucose, leukocytes, urea, creatinine, LDH levels in BAL, plasma MDA, AST and ALT levels in the sepsis+saline group. The use of CAPE significantly decreased these parameters. Histopathological examination revealed less congestion, portal inflammation, and focal necrosis of the liver, and less congestion, edema, and emphysematous and inflammatory changes in the lung in the sepsis+CAPE group than in the other groups. These results support that CAPE may be used for the treatment of organ failure during sepsis.en_US
dc.identifier.doi10.1007/s10753-008-9075-1
dc.identifier.endpage280en_US
dc.identifier.issn0360-3997
dc.identifier.issn1573-2576
dc.identifier.issue4en_US
dc.identifier.pmid18607706en_US
dc.identifier.scopus2-s2.0-47549101206en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage273en_US
dc.identifier.urihttps://doi.org/10.1007/s10753-008-9075-1
dc.identifier.urihttps://hdl.handle.net/11616/94595
dc.identifier.volume31en_US
dc.identifier.wosWOS:000257725800009en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer/Plenum Publishersen_US
dc.relation.ispartofInflammationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectsepsisen_US
dc.subjectratsen_US
dc.subjecttreatmenten_US
dc.subjectCAPEen_US
dc.titleEffects of caffeic acid phenethyl ester (CAPE) on sepsis in ratsen_US
dc.typeArticleen_US

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