Hesperidin protects testicular and spermatological damages induced by cisplatin in rats

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dc.authoridTR231039en_US
dc.authoridTR102040en_US
dc.authoridTR52354en_US
dc.authoridTR116821en_US
dc.authoridTR103979en_US
dc.contributor.authorKaya, Kürşat
dc.contributor.authorÇiftçi, Osman
dc.contributor.authorÇetin, Aslı
dc.contributor.authorDoğan, Halef
dc.contributor.authorBaşak, Neşe
dc.date.accessioned2017-04-17T12:22:13Z
dc.date.available2017-04-17T12:22:13Z
dc.date.issued2015
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe clinic usage of cisplatin, an anticancer drug, is limited due to it has many side effects in many systems and organs. In this context, it was aimed to investigate the protective effect of hesperidin, a citrus flavonoid, on testicular and spermatological damages induced by cisplatin in rats. The rats were randomly divided into four groups. The first group was kept as a control. In the second groups, cisplatin was given at the single dose of 7 mg kg(-1) intraperitoneally. In the third group, hesperidin was orally administered at the dose of 50 mg/kg day(-1) for 14 days. In the fourth group, cisplatin and hesperidin were given together at the same doses. Cisplatin treatment caused significant reductions enzymatic (SOD, CAT and GPx) and nonenzymatic (GSH) antioxidants and significant induction level of TBARS. In addition, cisplatin treatment caused decreased sperm motility, epididymal sperm concentration, increased abnormal sperm rate and histopathological damage. In contrast, hesperidin treatment significantly attenuated the harmful effects. In conclusion, this study clearly demonstrated that hesperidin has protective effects on cisplatin-induced reproductive system toxicity depending on its antioxidant properties. Thus, it is thought that hesperidin may be useful against cisplatin toxicity in patients with cancer in terms of reproductive system.en_US
dc.identifier.citationKaya, K. Çiftçi, O. Çetin, A. Doğan, H..Başak, N. 2015. Hesperidin protects testicular and spermatological damages induced by cisplatin in rats. Andrologia. 47(7):793-800.en_US
dc.identifier.doi10.1111/and.12332en_US
dc.identifier.endpage800en_US
dc.identifier.issue7en_US
dc.identifier.startpage793en_US
dc.identifier.urihttps://hdl.handle.net/11616/6678
dc.identifier.volume47en_US
dc.language.isoenen_US
dc.publisherAndrologiaen_US
dc.relation.ispartofAndrologiaen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCisplatinen_US
dc.subjectHesperidinen_US
dc.subjectOxidative stressen_US
dc.subjectSperm motilityen_US
dc.subjectTestisen_US
dc.titleHesperidin protects testicular and spermatological damages induced by cisplatin in ratsen_US
dc.typeArticleen_US

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