Extracorporeal photopheresis in steroid-refractory chronic graft-versus-host disease: A retrospective multicenter study

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dc.authoridNalcaci, Meliha/0000-0002-2555-5024
dc.authoridKAYA, Emin/0000-0001-8605-8497
dc.authoridErkurt, Mehmet Ali/0000-0002-3285-417X
dc.authoridKalayoglu Besisik, Sevgi/0000-0002-9310-1278
dc.authorwosidKALAYOGLU BESİSİK, SEVGİ/HNO-9101-2023
dc.authorwosidNalcaci, Meliha/AAC-2677-2020
dc.authorwosidKAYA, Emin/W-2951-2017
dc.authorwosidYonal-Hindilerden, Ipek/KOC-6710-2024
dc.authorwosidErkurt, Mehmet Ali/ABI-7232-2020
dc.authorwosidUlas, Turgay TU/A-6050-2018
dc.contributor.authorDal Sinan, Mehmet
dc.contributor.authorBatgi, Hikmettullah
dc.contributor.authorErkurt, Mehmet Ali
dc.contributor.authorHindilerden, Ipek Yonal
dc.contributor.authorKuku, Irfan
dc.contributor.authorKurtoglu, Erdal
dc.contributor.authorKaya, Emin
dc.date.accessioned2024-08-04T20:50:35Z
dc.date.available2024-08-04T20:50:35Z
dc.date.issued2021
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground and objectives: Extracorporeal photopheresis (ECP) is a treatment strategy in steroid-refractory chronic graft-versus-host disease (cGvHD). In this study, we aimed to share our multicenter experience using ECP in our steroid-refractory cGvHD patients. Materials and methods: In this multicenter observational retrospective study with the participation of four Turkish transplant centers, 100 patients with the diagnosis of steroid-refractory cGvHD who underwent ECP were analyzed. All ECP procedures were performed with the off-line system. Results: Severe cGvHD was observed in 77 % of the patients. 50 % of the patients had more than 1 organ involvement. The overall response rate in cGvHD was 58 %, and the complete response (CR) rate was 35 %. The skin was the most involved organ, with a response rate of 61.2 % (CR rate 30.6 %) in cGvHD. At a median 13 months (1-261) follow-up, overall survival (OS) was 41 % (n = 41) and the mortality rate was 59 % (n = 59). Median overall survival (OS) was 2 months for non-responders and 91 months for responders (p < 0.001). Significant OS differences were observed for patients responding to ECP in cGvHD (HR = 4.1, p = 0.001) patients. Conclusions: ECP is a good therapeutic alternative and could be used earlier in patients with steroid-resistant cGvHD.en_US
dc.identifier.doi10.1016/j.transci.2021.103243
dc.identifier.issn1473-0502
dc.identifier.issn1878-1683
dc.identifier.issue5en_US
dc.identifier.pmid34420879en_US
dc.identifier.scopus2-s2.0-85113617440en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.urihttps://doi.org/10.1016/j.transci.2021.103243
dc.identifier.urihttps://hdl.handle.net/11616/100164
dc.identifier.volume60en_US
dc.identifier.wosWOS:000697004600024en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofTransfusion and Apheresis Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectExtracorporeal photopheresisen_US
dc.subjectAllogenic stem cell transplantationen_US
dc.subjectChronic graft versus host diseaseen_US
dc.titleExtracorporeal photopheresis in steroid-refractory chronic graft-versus-host disease: A retrospective multicenter studyen_US
dc.typeArticleen_US

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