Airway inflammatory markers in chronic obstructive pulmonary disease patients and healthy smokers

Basit Öğe Kaydı
dc.authoridHacievliyagil, Suleyman Savas/0000-0002-2572-1870
dc.authoridMutlu, Levent Cem/0000-0002-3535-5704
dc.authorwosidMutlu, Levent Cem/HII-6048-2022
dc.authorwosidHacievliyagil, Suleyman Savas/ABI-7307-2020
dc.authorwosidMutlu, Levent Cem/AAZ-5186-2020
dc.contributor.authorHacievliyagil, S. S.
dc.contributor.authorMutlu, L. C.
dc.contributor.authorTemel, I.
dc.date.accessioned2024-08-04T20:37:24Z
dc.date.available2024-08-04T20:37:24Z
dc.date.issued2013
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: Cigarette smoke with its toxic ingredients leads to chronic inflammations in the airways. Objectives: In this study, the effect of cigarette smoke on the levels of inflammatory markers, interleukin-6 (IL-6), interleukin-8 (IL-8), and tumor necrosis factor-alpha (TNF-) in induced sputum was investigated. Materials and Methods: Twenty patients with chronic obstructive pulmonary disease (COPD) (group I), 20 healthy smokers (group II), and 20 healthy nonsmokers (group III) were included in the study. The levels of IL-6, IL-8, and TNF- in induced sputum were measured in these groups, and comparison analysis between the groups and correlation analysis for smoking load (pack-years) and spirometric parameters were performed. Results: Mean age of the patients in groups I, II, and III were 61.2 1.7, 58.2 1.6, and 59.1 5.4 years, respectively (P > 0.05). Smoking loads of group I and group II were 38.6 2.1 and 29.5 2.3 pack-years, respectively (P < 0.05). All cytokine levels were significantly higher in group I than groups II and III (P < 0.05). In addition to this, mean cytokines levels were significantly higher in group II than group III (P < 0.05). Smoking load of group II subjects was positively correlated with IL-6, IL-8, and TNF- in induced sputum (P < 0.05). Conclusions: We found that inflammatory marker levels in induced sputum were significantly higher in COPD patients and smokers than nonsmokers. Moreover, there was a moderate positive correlation between IL-6, IL-8, and TNF- levels and smoking load in the healthy smokers. We think that further studies are needed to determine whether higher levels of cytokine levels in sputum might be helpful in predicting the healthy smokers who will develop COPD in future.en_US
dc.identifier.doi10.4103/1119-3077.106771
dc.identifier.endpage81en_US
dc.identifier.issn1119-3077
dc.identifier.issue1en_US
dc.identifier.pmid23377476en_US
dc.identifier.scopus2-s2.0-84873669995en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage76en_US
dc.identifier.urihttps://doi.org/10.4103/1119-3077.106771
dc.identifier.urihttps://hdl.handle.net/11616/95947
dc.identifier.volume16en_US
dc.identifier.wosWOS:000316363600017en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMedknow Publications & Media Pvt Ltden_US
dc.relation.ispartofNigerian Journal of Clinical Practiceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectChronic obstructive pulmonary diseaseen_US
dc.subjectinflammatory markersen_US
dc.subjectinduced sputumen_US
dc.subjectIL-6en_US
dc.subjectIL-8en_US
dc.subjectTNF-alphaen_US
dc.titleAirway inflammatory markers in chronic obstructive pulmonary disease patients and healthy smokersen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu