The effects of single-dose dexamethasone on wound healing in rats

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dc.authoridkaraaslan, erol/0000-0002-8534-3680
dc.authoridErsoy, Mehmet/0000-0002-0724-2825
dc.authoridDurmus, Mahmut/0000-0001-9594-9064;
dc.authorwosidkaraaslan, erol/ABI-2700-2020
dc.authorwosidErsoy, Mehmet/ACN-2779-2022
dc.authorwosidDurmus, Mahmut/ABH-3006-2020
dc.authorwosidÖztürk, Emine/JHT-6711-2023
dc.contributor.authorDurmus, M
dc.contributor.authorKaraaslan, E
dc.contributor.authorOzturk, E
dc.contributor.authorGulec, M
dc.contributor.authorIraz, M
dc.contributor.authorEdali, N
dc.contributor.authorErsoy, MO
dc.date.accessioned2024-08-04T20:13:28Z
dc.date.available2024-08-04T20:13:28Z
dc.date.issued2003
dc.departmentİnönü Üniversitesien_US
dc.description.abstractDexamethasone effectively decreases the incidence of nausea and vomiting among pediatric and adult patients. In this study, we evaluated the effects of single-dose dexamethasone on wound healing in a prospective, randomized, experimental animal model. Anesthesia was induced with thiopental 100 mg/kg intraperitoneally. Dexamethasone 1 mg/kg was administered intraperitoneally in a dexamethasone group, and physiological saline was administered in a control group. Collagenization, epithelization, and fibroblast content were significantly less in the dexamethasone group compared with the control group (P values of 0.002, 0.041, and 0.023, respectively). The vascularity and the degree of inflammatory cells were more intense in the dexamethasone group compared with the control group (P values of 0.023 and 0.002, respectively). The white blood cell count was similar in the control (7.84 +/- 2.09) and dexamethasone (6.98 +/- 2.12) groups. The mean hydroxyproline level was 0.72 +/- 0.13 mg/g in the dexamethasone and 1.03 +/- 0.19 mg/g in the control group. Hydroxyproline levels were significantly less in the dexamethasone group (P = 0.001). We conclude that dexamethasone at I mg/kg may have negative effects on wound healing.en_US
dc.identifier.doi10.1213/01.ANE.0000080611.29106.9E
dc.identifier.endpage1380en_US
dc.identifier.issn0003-2999
dc.identifier.issue5en_US
dc.identifier.pmid14570655en_US
dc.identifier.scopus2-s2.0-0142212378en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage1377en_US
dc.identifier.urihttps://doi.org/10.1213/01.ANE.0000080611.29106.9E
dc.identifier.urihttps://hdl.handle.net/11616/93643
dc.identifier.volume97en_US
dc.identifier.wosWOS:000186143600031en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofAnesthesia and Analgesiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPostoperative Nauseaen_US
dc.subjectFibronectinen_US
dc.subjectDecreasesen_US
dc.subjectSteroidsen_US
dc.subjectCollagenen_US
dc.subjectChildrenen_US
dc.subjectVitaminen_US
dc.subjectInjuryen_US
dc.subjectMatrixen_US
dc.subjectRepairen_US
dc.titleThe effects of single-dose dexamethasone on wound healing in ratsen_US
dc.typeArticleen_US

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