Synthesis of Small-Sized Mesoporous Silica Nanoparticles by Experimental Design and Characterization for Further Drug Delivery

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dc.authoridTonbul, Hayrettin/0000-0001-5510-8973
dc.authoridŞahin, Adem/0000-0002-3996-2931
dc.authoridUltav, Gozde/0000-0001-5582-3766
dc.authoridCapan, Yilmaz/0000-0003-1234-9018
dc.authorwosidAktaş, Yeşim/ABB-3264-2020
dc.authorwosidÇapan, Yılmaz/AAM-5292-2021
dc.authorwosidTonbul, Hayrettin/AAR-6961-2020
dc.authorwosidUltav, Gözde/JPK-6247-2023
dc.authorwosidŞahin, Adem/IYT-0077-2023
dc.contributor.authorTonbul, Hayrettin
dc.contributor.authorUltav, Gozde
dc.contributor.authorAkbas, Sedenay
dc.contributor.authorSahin, Adem
dc.contributor.authorAktas, Yesim
dc.contributor.authorCapan, Yilmaz
dc.date.accessioned2024-08-04T20:46:57Z
dc.date.available2024-08-04T20:46:57Z
dc.date.issued2019
dc.departmentİnönü Üniversitesien_US
dc.description.abstractStudies on the use of mesoporous silica nanoparticles (MSNs) as a drug delivery system are increasing every year. The present study focused on the synthesis of small-sized MSNs for future drug delivery application. The MSNs with an approximate size of 50 nm with low polydispersity index (PDI) and high synthesis yield were obtained using the technique for order preference by similarity to ideal solution (TOPSIS) based in Taguchi design. The optimized MSN formulation was fully characterized and biocompatibility of this formulation was evaluated. The results demonstrated that optimized MSNs' average particle size was 53.2 nm, PDI was 0.125 and the synthesis yield was 84%. Moreover, obtained nanoparticles had a spherical shape and offer quite high drug loading area. Biocompatibility data also show that obtained MSN's were not reducing cell viability below 80% up to 32 mu g/mL concentration. Results indicated that obtained MSNs might be a promising approach for further drug delivery application.en_US
dc.description.sponsorshipScience and Technical Research Council of Turkey (TUBITAK) [216S999]en_US
dc.description.sponsorshipFTIR analyses were performed in ILKO ARGEM. TEM, SEM, EDX, N2 adsorption/desorption measurements and SAXRD analyses were performed in Middle East Technical University Central Laboratory. This research was supported by The Science and Technical Research Council of Turkey (TUBITAK) [grant numbers: 216S999].en_US
dc.identifier.endpage2210en_US
dc.identifier.issn0326-2383
dc.identifier.issue11en_US
dc.identifier.scopus2-s2.0-85075741785en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage2204en_US
dc.identifier.urihttps://hdl.handle.net/11616/99076
dc.identifier.volume38en_US
dc.identifier.wosWOS:000501866900012en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherColegio Farmaceuticos Provincia De Buenos Airesen_US
dc.relation.ispartofLatin American Journal of Pharmacyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectbiocompatibilityen_US
dc.subjectdrug deliveryen_US
dc.subjectexperimental designen_US
dc.subjectmesoporous silica nanoparticlesen_US
dc.subjectMSNen_US
dc.titleSynthesis of Small-Sized Mesoporous Silica Nanoparticles by Experimental Design and Characterization for Further Drug Deliveryen_US
dc.typeArticleen_US

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