Effects of central irisin administration on the uncoupling proteins in rat brain

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dc.authoridSandal, Suleyman/0000-0002-8916-3329
dc.authoridTekin, Suat/0000-0002-2757-1802
dc.authoridTektemur, Ahmet/0000-0002-2476-0413
dc.authoridErden, Yavuz/0000-0002-2807-6096
dc.authorwosidTektemur, Ahmet/V-8755-2018
dc.authorwosidSandal, Suleyman/AAA-6388-2021
dc.authorwosidTekin, Suat/AAG-1440-2021
dc.authorwosidTekin, Suat/IZD-9868-2023
dc.authorwosidTekin, Suat/KEI-2266-2024
dc.authorwosidErden, Yavuz/IZE-2291-2023
dc.authorwosidErden, Yavuz/AAJ-7783-2021
dc.contributor.authorErden, Yavuz
dc.contributor.authorTekin, Suat
dc.contributor.authorSandal, Suleyman
dc.contributor.authorOnalan, Ebru Etem
dc.contributor.authorTektemur, Ahmet
dc.contributor.authorKirbag, Sevda
dc.date.accessioned2024-08-04T20:41:36Z
dc.date.available2024-08-04T20:41:36Z
dc.date.issued2016
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIrisin is a thermogenic peptide that enables the development of brown adipose tissue from white adipose tissue by activating the UCP1. This study has been designed to determine the effects of the irisin on UCPs. Sprague Dawley female rats were used in the study. 1, 3 and 10 mu M concentrations of irisin were injected intracerebroventricularly to the rats, and the control group was received only vehicle. The animals were killed at the 16, 24, and 48 h time intervals and their brains were taken out. The hypothalamus, pituitary gland, hippocampus, cerebellum, striatum and cortex areas were separated and the UCP2, UCP3, UCP4 and UCP5 mRNA levels were determined. Just before the animals were killed, their body temperatures were recorded. It was observed that after application of the high dose irisin, UCP5 mRNA level in the all brain areas increased (p < 0.05); it was also observed that the three doses decreased the UCP4 expression in all brain areas (except the pituitary gland; p < 0.05). The UCP2 and UCP3 mRNA expressions showed significantly increase in cerebellum and striatum (p < 0.05). The UCP2 mRNA expression decreased in hypothalamus, pituitary gland, hippocampus and cortex areas (p < 0.05). It was also observed that the body temperatures of the rats increased depending on the irisin injection and this increase was the most considerable at the 24h (p < 0.05). The results of this study suggest that the UCP2-5 is expressed in different areas of the brain, and the irisin affects this expression, and may have effective roles in some brain functions. (C) 2016 Elsevier Ireland Ltd. All rights reserved.en_US
dc.description.sponsorshipFirat University Scientific Research Projects Coordination Unit [FF.13.26]en_US
dc.description.sponsorshipThis work was supported by the Firat University Scientific Research Projects Coordination Unit (Project No: FF.13.26). The authors would like to thank Dr. Cemil Colak of Inonu University Medical School for his advice in the statistical evaluation the data.en_US
dc.identifier.doi10.1016/j.neulet.2016.02.046
dc.identifier.endpage13en_US
dc.identifier.issn0304-3940
dc.identifier.issn1872-7972
dc.identifier.pmid26926562en_US
dc.identifier.scopus2-s2.0-84959441128en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage6en_US
dc.identifier.urihttps://doi.org/10.1016/j.neulet.2016.02.046
dc.identifier.urihttps://hdl.handle.net/11616/97205
dc.identifier.volume618en_US
dc.identifier.wosWOS:000374610100002en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Ireland Ltden_US
dc.relation.ispartofNeuroscience Lettersen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectIrisinen_US
dc.subjectUCP2en_US
dc.subjectUCP3en_US
dc.subjectUCP4en_US
dc.subjectUCP5en_US
dc.subjectRat brainen_US
dc.subjectBody temperatureen_US
dc.titleEffects of central irisin administration on the uncoupling proteins in rat brainen_US
dc.typeArticleen_US

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