Apheresis in patients with sepsis: A multicenter retrospective study

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dc.authoridErkurt, Mehmet Ali/0000-0002-3285-417X
dc.authoridAYDIN, KANİYE/0000-0001-5538-3692
dc.authoridSARICI, Ahmet/0000-0002-5916-0119;
dc.authorwosidErkurt, Mehmet Ali/ABI-7232-2020
dc.authorwosidKorkmaz, Serdal/IST-3736-2023
dc.authorwosidAYDIN, KANİYE/KRQ-6358-2024
dc.authorwosidSARICI, Ahmet/ABI-7512-2020
dc.authorwosidUlas, Turgay TU/A-6050-2018
dc.contributor.authorAydin, Kaniye
dc.contributor.authorKorkmaz, Serdal
dc.contributor.authorErkurt, Mehmet Ali
dc.contributor.authorSarici, Ahmet
dc.contributor.authorEkinci, Omer
dc.contributor.authorBaysal, Nuran Ahu
dc.contributor.authorBerber, Ilhami
dc.date.accessioned2024-08-04T20:50:33Z
dc.date.available2024-08-04T20:50:33Z
dc.date.issued2021
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground and objectives: To consider the effectiveness of apheresis, which is a supportive treatment method, in sepsis. Materials and methods: A hundred and eleven adults with sepsis or septic shock were included in this retrospective study. The demographic characteristics of the patients, the focus and source of infection causing sepsis or septic shock, characteristics of the pathogen, Acute Physiological and Chronic Health Assessment (APACHE) II score, routine laboratory values, which apheresis method was used, the characteristics of the replacement fluids used during the apheresis procedure, the number of apheresis procedures, complications related to the apheresis procedure, the follow-up time after the procedure, and mortality were recorded. The primary outcome was 28day mortality. Results: Sixty-nine (62.2 %) of the patients were male. The mean age of the patients was 47.7 +/- 18.6 years. The most common source of sepsis was hospital-acquired (79.3 %), the most common pathogen causing sepsis was gram-negative bacteria (41.4 %), and the most common infection site was the respiratory tract (58.7 %). The median APACHE II score was 19 (13-24). 92 (82.9 %) of the patients had septic shock. Theropeutic plasma exchange (TPE) was performed in 11.7 % of the patients and immunoabsorbtion IA in 88.3 %. The median number of sessions was 3 (3-5). No procedure-related fatal complication was observed in the study. While 28day mortality was 61.3 % in all patients, when the mortality according to the apheresis procedures was examined, it was 11.3 % and 88.2 % in the patients who underwent TPE and IA, respectively. The most common cause of mortality was multiorgan failure. Conclusions: Apheresis in sepsis can be considered as a salvage treatment. The indication for apheresis in sepsis is still at the level of patient-based individualized decision in line with the studies done so far, including our study. However, there is a need for a multicenter randomized controlled study with a large number of patients in order to give positive or negative recommendations about its effectiveness.en_US
dc.identifier.doi10.1016/j.transci.2021.103239
dc.identifier.issn1473-0502
dc.identifier.issn1878-1683
dc.identifier.issue5en_US
dc.identifier.pmid34412948en_US
dc.identifier.scopus2-s2.0-85112745524en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.urihttps://doi.org/10.1016/j.transci.2021.103239
dc.identifier.urihttps://hdl.handle.net/11616/100136
dc.identifier.volume60en_US
dc.identifier.wosWOS:000697004600019en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofTransfusion and Apheresis Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSepsisen_US
dc.subjectMultiorgan failureen_US
dc.subjectApheresisen_US
dc.subjectTherapeutic plasma exchangeen_US
dc.subjectImmunadsorptionen_US
dc.subjectMortalityen_US
dc.titleApheresis in patients with sepsis: A multicenter retrospective studyen_US
dc.typeArticleen_US

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