Melatonin Ameliorates Cerebral Vasospasm After Experimental Subarachnoidal Haemorrhage Correcting Imbalance of Nitric Oxide Levels in Rats

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dc.authoridParlakpinar, Hakan/0000-0001-9497-3468
dc.authoridAladag, M. Arif/0000-0003-3872-3741
dc.authoridTürköz, Yusuf/0000-0001-5401-0720
dc.authoridParlakpınar, Hakan/0000-0001-9497-3468
dc.authorwosidParlakpinar, Hakan/V-6637-2019
dc.authorwosidAladag, M. Arif/ABI-1182-2020
dc.authorwosidTürköz, Yusuf/ABG-7931-2020
dc.authorwosidParlakpınar, Hakan/T-6517-2018
dc.contributor.authorAladag, M. A.
dc.contributor.authorTurkoz, Y.
dc.contributor.authorParlakpinar, H.
dc.contributor.authorOzen, H.
dc.contributor.authorEgri, M.
dc.contributor.authorUnal, S. C.
dc.date.accessioned2024-08-04T20:31:19Z
dc.date.available2024-08-04T20:31:19Z
dc.date.issued2009
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIn the present study, we investigated the in vivo effects of melatonin on SAH-induced cerebral vasospasm and oxidative stress, resulting from SAH in an experimental rat model. Twenty-eight rats (225-250 g) were divided into four groups equally: group 1; control, group 2; SAH, group 3; SAH plus placebo, and group 4; SAH plus melatonin. We used double haemorrhage method for SAH groups. Beginning 6 h after SAH, 20 mg/kg melatonin or equal volume of 0.9% saline was administered intraperitoneally twice daily for 5 days to groups 3 and 4, respectively. Melatonin or 0.9% saline injections were continued up to fifth day after SAH and rats were sacrificed at the end of this period. Brain sections at the level of the pons were examined by light microscopy. The lumen diameter and the vessel wall thickness of basilar artery were measured using a micrometer. The serum levels of cerebral vasodilator nitric oxide (NO), the brain levels of an intrinsic antioxidant superoxide dismutase (SOD) and a NO regulator arginase activities were measured. The brain levels of inducible nitric oxide (iNOS) and nitrotyrosine, a nitrosative stress parameter immunohistochemiacally determined. In conclusion, melatonin administration ameliorated cerebral vasospasm by increasing serum NO level and decreasing the brain the levels of arginase and oxidative stress. It is therefore possible that increased brain arginase activity after SAH may also have a significant role in the pathogenesis of vasospasm by limiting the availability of arginine for NO production.en_US
dc.identifier.doi10.1007/s11064-009-9979-7
dc.identifier.endpage1944en_US
dc.identifier.issn0364-3190
dc.identifier.issn1573-6903
dc.identifier.issue11en_US
dc.identifier.pmid19415488en_US
dc.identifier.scopus2-s2.0-70349583529en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1935en_US
dc.identifier.urihttps://doi.org/10.1007/s11064-009-9979-7
dc.identifier.urihttps://hdl.handle.net/11616/94881
dc.identifier.volume34en_US
dc.identifier.wosWOS:000269914400007en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer/Plenum Publishersen_US
dc.relation.ispartofNeurochemical Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectOxidative stressen_US
dc.subjectVasospasmen_US
dc.subjectMelatoninen_US
dc.subjectSODen_US
dc.subjectArginaseen_US
dc.subjectNOen_US
dc.subjectiNOSen_US
dc.subjectNitrotyrosineen_US
dc.titleMelatonin Ameliorates Cerebral Vasospasm After Experimental Subarachnoidal Haemorrhage Correcting Imbalance of Nitric Oxide Levels in Ratsen_US
dc.typeArticleen_US

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