Synthesis of New 1-Aryl-2-(3,5-dimethylpyrazol-1-yl)ethanone Oxime Ether Derivatives and Investigation of Their Cytotoxic Effects

Basit Öğe Kaydı
dc.authoridalagoz, mehmet abdullah/0000-0001-5190-7196
dc.authoridKarakurt, Arzu/0000-0003-2209-0871
dc.authoridŞALVA, EMINE/0000-0002-1159-5850
dc.authoridOnkol, Tijen/0000-0003-3973-5728
dc.authoridGhoneim, Mohammed M./0000-0002-9179-4373
dc.authoridabdelgawad, mohamed/0000-0001-9035-5638
dc.authoridKim, Hoon/0000-0002-7203-3712
dc.authorwosidalagoz, mehmet abdullah/W-7847-2018
dc.authorwosidAbdelgawad, Mohamed A./X-5943-2019
dc.authorwosidKhames, Ahmed/AHD-9318-2022
dc.authorwosidKarakurt, Arzu/ABH-9340-2020
dc.authorwosidŞALVA, EMINE/CAH-3062-2022
dc.authorwosidOnkol, Tijen/AAA-2377-2021
dc.authorwosidGhoneim, Mohammed M./ABE-7965-2021
dc.contributor.authorAlagoz, Mehmet Abdullah
dc.contributor.authorKarakurt, Arzu
dc.contributor.authorHepokur, Ceylan
dc.contributor.authorSalva, Emine
dc.contributor.authorOnkol, Tijen
dc.contributor.authorGhoneim, Mohammed M.
dc.contributor.authorAbdelgawad, Mohamed A.
dc.date.accessioned2024-08-04T20:50:52Z
dc.date.available2024-08-04T20:50:52Z
dc.date.issued2021
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIn this study, 12 new 1-aryl-2-(3,5-dimethylpyrazol-1-yl)ethanone oxime ether derivatives were designed and synthesized to investigate their cytotoxic effects. The in vitro cytotoxic activities of the compounds were evaluated against cervix, colon, breast, glioma, neuroblastoma, and lung cancer cell lines, as well as a healthy cell line using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazo-lium bromide (MTT) assays with 5-fluorouracil (5-FU) as the reference compound. Compound 5f (IC50 = 5.13 mu M) was found to be more effective than 5-FU (IC50 = 8.34 mu M) in the C6 cancer cell line, and it had no cytotoxic effect on the L929 healthy cell line. Flow cytometry was used to investigate the mechanism of action of compound 5f on the cell cycle of the C6 cell line. The analysis showed that cell death was significantly due to apoptosis. These results indicate that compound 5f induces cell cycle arrest, and may be effective in treating glioma.en_US
dc.description.sponsorshipTaif University, Taif, Saudi Arabia [TURSP-2020/68]en_US
dc.description.sponsorshipTaif University Researchers Supporting Project number (TURSP-2020/68), Taif University, Taif, Saudi Arabia.en_US
dc.identifier.doi10.3390/pr9112019
dc.identifier.issn2227-9717
dc.identifier.issue11en_US
dc.identifier.scopus2-s2.0-85119591126en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.3390/pr9112019
dc.identifier.urihttps://hdl.handle.net/11616/100322
dc.identifier.volume9en_US
dc.identifier.wosWOS:000724218100001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherMdpien_US
dc.relation.ispartofProcessesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subject3,5-dimethylpyrazoleen_US
dc.subjectoxime etheren_US
dc.subjectcytotoxic activityen_US
dc.subjectgliomaen_US
dc.subjectneuroblastomaen_US
dc.titleSynthesis of New 1-Aryl-2-(3,5-dimethylpyrazol-1-yl)ethanone Oxime Ether Derivatives and Investigation of Their Cytotoxic Effectsen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu