Leflunomide induced fatal dress syndrome need liver transplantation

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dc.authorid0000-0003-3187-8548
dc.authorid0000-0002-1713-5695
dc.contributor.authorÇalışkan, Ali Rıza
dc.date.accessioned2026-01-19T09:42:14Z
dc.date.available2026-01-19T09:42:14Z
dc.date.issued2024
dc.departmentFakülteler, Sağlık Bilimleri Fakültesi, Beslenme ve Diyetetik Bölümü
dc.description.abstractDrug reaction with eosinophilia and systemic symptoms (DRESS) syn- drome is a severe, potentially life-threatening, drug-induced hypersensi- tivity reaction that involves hematological abnormalities (atypical lym- phocytosis, eosinophilia), lymphadenopathy, skin eruption, and internal organ involvement (lung, liver, kidney). The 36-year-old female patient was followed by bloody diarrhea, diffuse skin rashes and hepatitis. She was diagnosed with psoriatic arthritis, and Leflunomide 20 mg was added to the treatment six weeks ago. Upon developing hepatic encephalopathy and deepening the fulminant liver failure during the follow-up, a living donor liver from her son was transplanted on the 4th day of hospitalization. The patient had deceased on the second day after liver transplantation due to multiple organ failures. In the literature, mortality in DRESS syndrome is mostly secondary to hepatic failure. Liver transplantation cannot be effec- tive due to systemic involvement and recurrence in the transplanted liver.
dc.identifier.citationÇALIŞKAN, A. R., ERDOGAN, M. A. (2024). Leflunomide induced fatal dress syndrome need liver transplantation. Hepatology forum , 5(4), 204 - 206. doi.org/10.14744/hf.2024.2024.0010
dc.identifier.endpage206
dc.identifier.issn1307-5888
dc.identifier.issue4
dc.identifier.startpage204
dc.identifier.urihttps://hdl.handle.net/11616/106327
dc.identifier.volume5
dc.language.isoen
dc.publisherİnönü Üniversitesi
dc.relation.ispartofHepatology forum
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectLeflunomide
dc.subjectDrug reaction
dc.subjectliver transplantation.
dc.titleLeflunomide induced fatal dress syndrome need liver transplantation
dc.typeArticle

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