Relationship between methylation pattern of the SYN2 gene and schizophrenia

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dc.contributor.authorFettahoglu, İbrahim
dc.contributor.authorKartalcı, Şükrü
dc.contributor.authorGözükara Bag, Harika Gözde
dc.contributor.authorAcar, Ceren
dc.date.accessioned2026-01-14T07:44:40Z
dc.date.available2026-01-14T07:44:40Z
dc.date.issued2024
dc.departmentEnstitüler, Fen Bilimleri Enstitüsü, Moleküler Biyoloji ve Genetik Ana Bilim Dalı
dc.departmentEnstitüler, Fen Bilimleri Enstitüsü, Fizik Ana Bilim Dalı
dc.description.abstractObjectives: Schizophrenia is a neuropsychiatric disease, and its etiology is not exactly understood. DNA methylation is an important phenomenon that affects the rise of abnormal phe- notypes in many cases. Investigation of the association between DNA methylation and schizophrenia is crucial for elucidating the basis of schizophrenia. Previous association studies confirm that the SYN2 gene is a strong candidate gene for schizophrenia. In the current study, the relationship between the methylation status of the SYN2 gene and schizophrenia was investigated. The aim is to obtain crucial results for illuminating the effects of the SYN2 methylation changes in the etiology of schizophrenia. Methods: In light of this scientific information, we investi- gated the methylation status of three different CpG regions in the promoter of the SYN2 gene and compared them in healthy controls and schizophrenia patients. Thirty-three healthy controls and 36 schizophrenia patients were included in this study. Sequencing was performed using the pyrosequencing method to reveal the methylation pattern. Results: As a result of the statistical analysis, it was confirmed that there is a significant relationship between the methylation pattern of the SYN2 gene and schizophrenia. Schizophrenia patients showed more methylation in position 2 and position 3. Additionally, the average methylation ratio is increased in schizophrenia patients. Conclusions: We find an association between the DNA methylation pattern of the SYN2 gene and schizophrenia. These results can help to the understanding of the etiology of schizophrenia. Except for these, DNA methylation changes in the SYN2 gene in people who live in urban and rural areas can be one of the reasons for the different incidences of schizophrenia in these regions.
dc.identifier.citationFETTAHOGLU, I., KARTALCI, Ş., BAG, H. G. G., ACAR, C. (2024). Relationship between methylation pattern of the SYN2 gene and schizophrenia. Türk Biyokimya Dergisi , 49(3), 383 - 389. doi.org/10.1515/tjb-2023-0249
dc.identifier.endpage389
dc.identifier.issue3
dc.identifier.startpage383
dc.identifier.urihttps://hdl.handle.net/11616/106315
dc.identifier.volume49
dc.language.isoen
dc.publisherİnönü Üniversitesi
dc.relation.ispartofTürk Biyokimya Dergisi
dc.relation.ispartofseries1303-829X
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectDNA methylation
dc.subjectschizophrenia
dc.subjectSYN2
dc.subjectepige- netics
dc.subjectsynapse
dc.titleRelationship between methylation pattern of the SYN2 gene and schizophrenia
dc.typeArticle

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