Resveratrol may reduce apoptosis of rat testicular germ cells after experimental testicular torsion

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dc.authoridUĞURALP, SEMA/0000-0002-7628-0550
dc.authorwosidUĞURALP, SEMA/ABH-6309-2020
dc.contributor.authorUguralp, S
dc.contributor.authorUsta, U
dc.contributor.authorMizrak, B
dc.date.accessioned2024-08-04T20:15:20Z
dc.date.available2024-08-04T20:15:20Z
dc.date.issued2005
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe aim of the study is to evaluate the effects of resveratrol on apoptosis of testicular germ cells after experimental testicular torsion. Thirty Wistar albino rats were divided into 3 groups. Torsions were created by rotating the right testis 720 degrees in a clockwise direction for 4 h in all groups except the control group (group 1). They were then repaired by counter-rotation and replaced into the scrotum. In group 2, saline was infused 30 min before detorsion. In group 3, 30 mg/kg resveratrol was infused 30 min before detorsion. In groups 2 and 3, the bilateral testes were removed to determine germ cell apoptosis after 20 h of detorsion. The number of apoptotic cells was evaluated using the terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick-end labeling (TUNEL) technique and caspase 3. Mean apoptotic score of ipsilateral testes in group 3 was lower than that of group 2 (p < 0.05). Mean apoptotic score of the contralateral testes in group 3 was not different from that of group 2 (p > 0.05). The present study demonstrates that intraperitoneal administration of resveratrol in rats may decrease germ cell apoptosis in the ipsilateral testes.en_US
dc.identifier.doi10.1055/s-2005-865757
dc.identifier.endpage336en_US
dc.identifier.issn0939-7248
dc.identifier.issue5en_US
dc.identifier.pmid16254845en_US
dc.identifier.scopus2-s2.0-33644789253en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage333en_US
dc.identifier.urihttps://doi.org/10.1055/s-2005-865757
dc.identifier.urihttps://hdl.handle.net/11616/94297
dc.identifier.volume15en_US
dc.identifier.wosWOS:000233110500005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherGeorg Thieme Verlag Kgen_US
dc.relation.ispartofEuropean Journal of Pediatric Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectresveratrolen_US
dc.subjecttestisen_US
dc.subjectapoptosisen_US
dc.subjecttorsionen_US
dc.subjecttreatmenten_US
dc.titleResveratrol may reduce apoptosis of rat testicular germ cells after experimental testicular torsionen_US
dc.typeArticleen_US

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