Apoptosis : programlı hücre ölümü veya indüklenmiş intihar
Yükleniyor...
Dosyalar
Tarih
1995
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
İnönü Üniversitesi Tıp Fakültesi Dergisi
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Apoptosis, intrinsik olarak programlanmış “hücre intihar girişimi” yani bir çeşit programlı hücre ölümüdür. Morfolojik olarak nükleer kromatinin koyulaşması, hücre yüzeyinde kabarcıkların oluşması ve DNA ’da kopmalar ile karakterizedir. Memelilerde T ve B lenfositlerinde ve timositlerde apoptosis görülmektedir. Özellikle iimoma ’da olmak üzere tümör radyoterapisi sırasında da apoptosis görülür. İyonizan radyasyon da periferik lenfositlerde apoptosisi indükler. p53 tümör süprese eden gen ve bcl-2 onkogen ’i hücrede görülen apoptosis ile yakından ilgili b ulunmuştur.
Programlı hücre ölümü kanser, AIDS, otoimmün hastalıklar ve santral sinir sisteminin dejeneratif hastalıklarında rol oynayabilir. Apoptosis, bu hastalıkların tedavisi ve önlenmesi için yeni farmakolojik imkanlar sunmaktadır.
Apoptosis is a kind of programmed cell death, that is, intrinsically programmed “cell suicide process”. Apoptosis is characterized morphologically by condensation of chromatin at the nucleary boundary, blebbing at the cell surface, and breakdown of DNA. Mammalian T and B lymphocytes, thymocytes, show a typical apoptosis immediately. Apoptosis appears also during radiotherapy of tumor, especially of thymoma. Ionizing radiation also induces apoptosis in peripheral mature lymphocytes. Tumor suppressor gene such as p53 and oncogene such as bcl-2 are j'ound to be closely related to apoptotic processes in a cell. Programmed cell death may play a part in the aetiology of cancer, AIDS, autoimmune diseases, and degenerative diseases of the central nervous system. The pharmacological manipulation of apoptosis offers new possibilities for the prevention and treatment of these illnesses.
Apoptosis is a kind of programmed cell death, that is, intrinsically programmed “cell suicide process”. Apoptosis is characterized morphologically by condensation of chromatin at the nucleary boundary, blebbing at the cell surface, and breakdown of DNA. Mammalian T and B lymphocytes, thymocytes, show a typical apoptosis immediately. Apoptosis appears also during radiotherapy of tumor, especially of thymoma. Ionizing radiation also induces apoptosis in peripheral mature lymphocytes. Tumor suppressor gene such as p53 and oncogene such as bcl-2 are j'ound to be closely related to apoptotic processes in a cell. Programmed cell death may play a part in the aetiology of cancer, AIDS, autoimmune diseases, and degenerative diseases of the central nervous system. The pharmacological manipulation of apoptosis offers new possibilities for the prevention and treatment of these illnesses.
Açıklama
Journal ofTurgut Ozal Medical Center 2(2) .206-220,1995
Anahtar Kelimeler
Apoptosis, Programmed cell death, Induced suicide, Cancer, Autoimmune disease, AIDS
Kaynak
Turgut Özal Tıp Merkezi Dergisi
WoS Q Değeri
Scopus Q Değeri
Cilt
2
Sayı
2
Künye
Özerol, İ. Halil.,(1995). Apoptosis : programlı hücre ölümü veya indüklenmiş intihar.Turgut Özal Tıp Merkezi Dergisi, 2 (2).206-260 ss.
