Factors associated with noninvasive ventilation response in the first day of therapy in patients with hypercapnic respiratory failure

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dc.authoridGulbas, Gazi/0000-0002-9435-8307
dc.authoridOzkaya, Sevket/0000-0002-8697-4919
dc.authorwosidGulbas, Gazi/ABI-5182-2020
dc.authorwosidOzkaya, Sevket/AAE-4521-2020
dc.contributor.authorGursel, Gul
dc.contributor.authorAydogdu, Muge
dc.contributor.authorTasyurek, Secil
dc.contributor.authorGulbas, Gazi
dc.contributor.authorOzkaya, Sevket
dc.contributor.authorNazik, Sakine
dc.contributor.authorDemir, Ayse
dc.date.accessioned2024-08-04T20:35:51Z
dc.date.available2024-08-04T20:35:51Z
dc.date.issued2012
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground and Aim: Noninvasive ventilation (NIV) decreases mechanical ventilation indication in the early period of acute hypercapnic respiratory failure (AHcRF) and factors for success have been studied well. But, less is known about the factors influencing the NIV response in the subacute period. This study was aimed to determine the factors influencing the reduction of PaCO 2 levels within first 24 hours of therapy. Methods: NIV response was defined as reduction of PaCO 2 level below 50 mmHg within first 24 hours. Patients with AHcRF, treated with NIV, were divided into 2 groups according to this criterion; group 1 as the nonresponsive, group 2 as the responsive. The differences in NIV methods and characteristics of the two groups were evaluated and compared in this retrospective study. Results: A total of 100 patients were included in the study; 66 of them in group 1 and 34 in group 2. No significant differences were identified between the length of NIV application and intensive care unit (ICU) stay, intubation and mortality rates, across the groups. Ninety-one percent of the patients in group 2 had received all night long NIV therapy; this was just 74 in group 1 (P=0.036). Results of multivariate analysis showed that while nocturnal application was significantly associated with better response, prior home ventilation and requirement of higher pressure support (PS) levels significantly and independently associated with poorer response to NIV therapy. Conclusion: In patients with AHcRF, all night long use of NIV may accelerate healing by improving PaCO 2 reduction within the first 24 hours. A rapid response in PaCO 2 levels should not be expected in patients requiring higher PS levels and using prior home ventilation.en_US
dc.identifier.doi10.4103/1817-1737.94531
dc.identifier.endpage97en_US
dc.identifier.issn1817-1737
dc.identifier.issn1998-3557
dc.identifier.issue2en_US
dc.identifier.pmid22558014en_US
dc.identifier.scopus2-s2.0-84859759977en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage92en_US
dc.identifier.urihttps://doi.org/10.4103/1817-1737.94531
dc.identifier.urihttps://hdl.handle.net/11616/95621
dc.identifier.volume7en_US
dc.identifier.wosWOS:000302745100008en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWolters Kluwer Medknow Publicationsen_US
dc.relation.ispartofAnnals of Thoracic Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectChronic obstructive pulmonary diseaseen_US
dc.subjectfirst dayen_US
dc.subjecthypercapnic respiratory failureen_US
dc.subjectnoninvasive ventilationen_US
dc.subjectresponseen_US
dc.titleFactors associated with noninvasive ventilation response in the first day of therapy in patients with hypercapnic respiratory failureen_US
dc.typeArticleen_US

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