Emission based sensing of N-acetyl cysteine via silver equipped anthraquinone derivatives

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dc.contributor.authorMumcu, Taskin
dc.contributor.authorOncuoglu, Serkan
dc.contributor.authorMumcu, Akin
dc.contributor.authorYilmaz, Ulku
dc.contributor.authorErtekin, Kadriye
dc.date.accessioned2026-04-04T13:34:50Z
dc.date.available2026-04-04T13:34:50Z
dc.date.issued2026
dc.departmentİnönü Üniversitesi
dc.description.abstractIn this work we investigated emission-based response of silver complexes of two newly synthesized anthraquinone derivatives for N-acetylcysteine (NAC) and thioglycolic acid. The interaction of the probes, DHAdibenzonitrile and DHA-dibutanenitrile with silver nanoparticles resulted in metal chelation and following quenching of the fluorescence. To determine whether the emission intensity of the complexes was re-stored again, thiol compounds; NAC and thioglycolic acid were used. The released dyes re-emitted light, allowing the system to exhibit an intensity-based turn-on type sensor behavior for the NAC and thioglycolic acid, respectively. The re-stored fluorescence was monitored as a strong emission based analytical signal at 560 nm. The complex stoichiometries were investigated using several approaches, including Job's plot, density functional theory (DFT) and FT-IR measurements. The findings relying on HOMO-LUMO and energy gap calculations highlight that Ag coordination and following acetylcysteine adduction significantly re-shape both local nucleophilic and electrophilic regions, modulating the global electronic structure and reactivity of anthraquinone derivatives. N-acetylcysteine exhibited an exceptional spectral response at pH 9.0 in a buffered solution exhibiting 13.6 and 14.4-fold enhancement in the emission intensity, respectively. The reported linear responses for a concentration range of; 1.0 x 10-5 M-1.0 x 10-2 M, can easily be adopted to determination of the NAC levels in drugs, in vitro studies or in serum samples. Limit of detection (LOD) and limit of quantification (LOQ) values of the DHA-dibutanenitrile derivative for the NAC molecule were found to be 1.28 x 10-6 and 1.21 x 10-5 mol x L-1, respectively. Similarly, the DHA-dibenzonitrile exhibited 1.11 x 10-6 and 1.28 x 10-5 mol x L-1 of LOD and LOQ values, respectively.
dc.description.sponsorshipScientific Research Funds of Dokuz Eylul University [2019.KB.FEN.002]
dc.description.sponsorshipFunding for this research was provided by the Scientific Research Funds of Dokuz Eylul University (project number: 2019.KB.FEN.002). We also would like to thank Dokuz Eylul University, Center for Fabr-cation and Application of Electronic Materials (EMUM) for contributions for the lifetime measurements.
dc.identifier.doi10.1016/j.saa.2025.127152
dc.identifier.issn1386-1425
dc.identifier.issn1873-3557
dc.identifier.orcid0000-0002-2806-4781
dc.identifier.pmid41223462
dc.identifier.scopus2-s2.0-105021227638
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.saa.2025.127152
dc.identifier.urihttps://hdl.handle.net/11616/109428
dc.identifier.volume348
dc.identifier.wosWOS:001620516400001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherPergamon-Elsevier Science Ltd
dc.relation.ispartofSpectrochimica Acta Part A-Molecular and Biomolecular Spectroscopy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250329
dc.subjectAnthraquinone
dc.subjectN -acetylcysteine
dc.subjectNAC
dc.subjectFluorescence
dc.subjectSensor
dc.titleEmission based sensing of N-acetyl cysteine via silver equipped anthraquinone derivatives
dc.typeArticle

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