The Effects of Antiperspirant Aluminum Chlorohydrate on the Development of Antibiotic Resistance in Staphylococcus epidermidis

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dc.authoridAras, Ayşe/0000-0001-7142-2401
dc.authoridTanriverdi, Elif Seren/0000-0002-0449-0356
dc.authoridGürpınar Rizvanoglu, Suna Sibel/0000-0003-4244-0920
dc.authoridEryilmaz, Mujde/0000-0003-3760-1996
dc.authorwosidAras, Ayşe/IRZ-3963-2023
dc.authorwosidTanriverdi, Elif Seren/ABE-4472-2021
dc.authorwosidGürpınar Rizvanoglu, Suna Sibel/AAG-3091-2020
dc.authorwosidEryilmaz, Mujde/AAG-8316-2019
dc.contributor.authorAras, Ayse
dc.contributor.authorRizvanoglu, Suna Sibel
dc.contributor.authorTanriverdi, Elif Seren
dc.contributor.authorKaraca, Basar
dc.contributor.authorEryilmaz, Mujde
dc.date.accessioned2024-08-04T20:53:41Z
dc.date.available2024-08-04T20:53:41Z
dc.date.issued2023
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThis study investigates the effects of the antiperspirant aluminum chlorohydrate on the development of antibiotic resistance in commensal Staphylococcus epidermidis isolates. The isolates were exposed to aluminum chlorohydrate for 30 days. The bacteria that developed resistance to oxacillin and ciprofloxacin were isolated, and the expression levels of some antibiotic resistance genes were determined using quantitative reverse transcriptase PCR. Before and after exposure, the minimum inhibitory concentration (MIC) values of the bacteria were determined using the microdilution method. A time-dependent increase was observed in the number of bacteria that developed resistance and increased MIC values. Consistent with the ciprofloxacin resistance observed after exposure, an increase in norA, norB/C, gyrA, gyrB, parC, and parE gene expression was observed. In addition to aluminum chlorohydrate exposure, oxacillin resistance was observed in all test bacteria in the group only subcultured in the medium, suggesting that phenotypic resistance cannot be correlated with chemical exposure in light of these data. The increase in mecA gene expression in selected test bacteria that acquired resistance to oxacillin after exposure compared with control groups suggests that the observed resistance may have been related to aluminum chlorohydrate exposure. To our knowledge, this is the first time in the literature that the effects of aluminum chlorohydrate as an antiperspirant on the development of antibiotic resistance in Staphylococcus epidermidis have been reported.en_US
dc.description.sponsorshipAnkara University Scientific Research Council [20L0237006]en_US
dc.description.sponsorshipThis research was funded by Ankara University Scientific Research Council, grant number 20L0237006.en_US
dc.identifier.doi10.3390/microorganisms11040948
dc.identifier.issn2076-2607
dc.identifier.issue4en_US
dc.identifier.pmid37110371en_US
dc.identifier.scopus2-s2.0-85156253180en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.3390/microorganisms11040948
dc.identifier.urihttps://hdl.handle.net/11616/101333
dc.identifier.volume11en_US
dc.identifier.wosWOS:000979626200001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMdpien_US
dc.relation.ispartofMicroorganismsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectaluminum chlorohydrateen_US
dc.subjectantibiotic resistanceen_US
dc.subjectminimum inhibitory concentrationen_US
dc.subjectquantitative reverse transcriptase PCRen_US
dc.subjectStaphylococcus epidermidisen_US
dc.titleThe Effects of Antiperspirant Aluminum Chlorohydrate on the Development of Antibiotic Resistance in Staphylococcus epidermidisen_US
dc.typeArticleen_US

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