Experimental heart failure models in small animals

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dc.authoridGunata, Mehmet/0000-0001-6905-4259
dc.authoridParlakpınar, Hakan/0000-0001-9497-3468
dc.authorwosidGunata, Mehmet/AAW-2738-2021
dc.authorwosidParlakpınar, Hakan/T-6517-2018
dc.contributor.authorGunata, Mehmet
dc.contributor.authorParlakpinar, Hakan
dc.date.accessioned2024-08-04T20:53:14Z
dc.date.available2024-08-04T20:53:14Z
dc.date.issued2023
dc.departmentİnönü Üniversitesien_US
dc.description.abstractHeart failure (HF) is one of the most critical health and economic burdens worldwide, and its prevalence is continuously increasing. HF is a disease that occurs due to a pathological change arising from the function or structure of the heart tissue and usually progresses. Numerous experimental HF models have been created to elucidate the pathophysiological mechanisms that cause HF. An understanding of the pathophysiology of HF is essential for the development of novel efficient therapies. During the past few decades, animal models have provided new insights into the complex pathogenesis of HF. Success in the pathophysiology and treatment of HF has been achieved by using animal models of HF. The development of new in vivo models is critical for evaluating treatments such as gene therapy, mechanical devices, and new surgical approaches. However, each animal model has advantages and limitations, and none of these models is suitable for studying all aspects of HF. Therefore, the researchers have to choose an appropriate experimental model that will fully reflect HF. Despite some limitations, these animal models provided a significant advance in the etiology and pathogenesis of HF. Also, experimental HF models have led to the development of new treatments. In this review, we discussed widely used experimental HF models that continue to provide critical information for HF patients and facilitate the development of new treatment strategies.en_US
dc.identifier.doi10.1007/s10741-022-10286-y
dc.identifier.endpage554en_US
dc.identifier.issn1382-4147
dc.identifier.issn1573-7322
dc.identifier.issue2en_US
dc.identifier.pmid36504404en_US
dc.identifier.scopus2-s2.0-85143687955en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage533en_US
dc.identifier.urihttps://doi.org/10.1007/s10741-022-10286-y
dc.identifier.urihttps://hdl.handle.net/11616/101048
dc.identifier.volume28en_US
dc.identifier.wosWOS:000897784300001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofHeart Failure Reviewsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAnimalen_US
dc.subjectHeart failureen_US
dc.subjectHypertensionen_US
dc.subjectMyocardial infarctionen_US
dc.subjectPressureen_US
dc.titleExperimental heart failure models in small animalsen_US
dc.typeReview Articleen_US

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