The levels of plasma and salivary antioxidants in the patient with recurrent aphthous stomatitis

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dc.authoridBatcioglu, Kadir/0000-0001-6663-2287
dc.authoridGenç, Metin Fikret/0000-0002-6244-0517
dc.authorwosidBatcioglu, Kadir/Q-2424-2015
dc.authorwosidGenç, Metin Fikret/ABI-2169-2020
dc.contributor.authorKarincaoglu, Y
dc.contributor.authorBatcioglu, K
dc.contributor.authorErdem, T
dc.contributor.authorEsrefoglu, M
dc.contributor.authorGenc, M
dc.date.accessioned2024-08-04T20:13:45Z
dc.date.available2024-08-04T20:13:45Z
dc.date.issued2005
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBACKGROUND: Despite plenty of research, the cause of recurrent aphthous stomatitis (RAS) remains obscure. It has been proposed that, the aetiological factors such as local trauma, smoking, vitamin deficiencies and viral infections lead to aphthae formation via final common pathway based on increased oxidative stress. The aim of this investigation was to evaluate the antioxidant enzyme superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSHPx) alterations in plasma and saliva, and in addition uric acid (UA) in saliva, in patients with RAS and healthy controls. METHODS: Thirty-two patients with RAS and 30 healthy controls were included into the study. The SOD, CAT, GSHPx and UA levels were measured in plasma and saliva in study and control groups. RESULTS: In the RAS group, although the mean SOD (P < 0.001) and CAT (P < 0.05) levels of plasma were lower, GSHPx (P < 0.001) levels were higher than control group. The salivary concentrations of the SOD (P < 0.001), CAT (P < 0.05) and GSHPx (P < 0.001) in RAS group were entirely opposite to plasma concentrations. UA were not significant between RAS group and controls. CONCLUSION: Since we found salivary SOD and CAT levels were high whereas plasma levels were low, it has been thought that, salivary defence mechanisms via antioxidant agents may be stimulated against to the ulcerous lesion. We consider that the organism might mobilize the antioxidant potential to the sites where they were needed. At this point, decrease of SOD and CAT levels in the plasma may be related to this shift. It is also thought that GSHPx secretion in the saliva may also be increased but the increase in its turnover may be responsible for the diminished activity.en_US
dc.identifier.doi10.1111/j.1600-0714.2004.00253.x
dc.identifier.endpage12en_US
dc.identifier.issn0904-2512
dc.identifier.issn1600-0714
dc.identifier.issue1en_US
dc.identifier.pmid15610400en_US
dc.identifier.scopus2-s2.0-12444272583en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage7en_US
dc.identifier.urihttps://doi.org/10.1111/j.1600-0714.2004.00253.x
dc.identifier.urihttps://hdl.handle.net/11616/93796
dc.identifier.volume34en_US
dc.identifier.wosWOS:000225792200002en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Oral Pathology & Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectantioxidantsen_US
dc.subjectrecurrent aphthhous stomatitisen_US
dc.subjectsalivaryen_US
dc.titleThe levels of plasma and salivary antioxidants in the patient with recurrent aphthous stomatitisen_US
dc.typeArticleen_US

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