Obesity as a modifying factor of periodontal therapy outcomes: local and systemic adipocytokines and oxidative stress markers

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dc.authoridToy, Vesile Elif/0000-0001-5183-6295
dc.authoridAtaoglu, Tamer/0000-0003-1937-0290
dc.authorwosidToy, Vesile Elif/ABH-9210-2020
dc.authorwosidAtaoglu, Tamer/AAL-2379-2021
dc.contributor.authorToy, Vesile Elif
dc.contributor.authorAtaoglu, Tamer
dc.contributor.authorEltas, Abubekir
dc.contributor.authorOtlu, Husniye Gul
dc.contributor.authorKarabulut, Aysun Bay
dc.date.accessioned2024-08-04T20:53:21Z
dc.date.available2024-08-04T20:53:21Z
dc.date.issued2023
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjectives Adipocytokines and oxidative stress (OS) are involved in the pathogenesis of both obesity and periodontitis. The aim of this study was to evaluate periodontal therapy outcomes in terms of serum and gingival crevicular fluid (GCF) levels of adipocytokines and OS markers in obese patients with periodontitis, in order to have an insight into the association between obesity and periodontitis.Materials and methods A total of 39 patients (20 obese, 19 non-obese) with periodontitis were included in this study. Clinical periodontal parameters were assessed; serum and GCF levels of adipocytokines and OS markers were evaluated by ELISA at baseline and 3 months after non-surgical periodontal therapy.Results Significant improvements in clinical periodontal parameters were observed in both groups at 3 months (p < 0.01). While serum levels of TNF-alpha, leptin, and total oxidant status (TOS) in the obese group were higher at baseline (p < 0.01), leptin levels remained higher at 3 months despite a significant decrease (p < 0.01). Although NSPT improved GCF levels of total antioxidant status (TAS) and TOS in both groups, they were significantly different between the groups after therapy (p < 0.05).Conclusions It seems that leptin, TNF-alpha, and TOS contribute to systemic inflammatory and oxidative state in patients with obesity. Despite improvements in clinical periodontal parameters, obesity might be a modulating factor in the development and progression of periodontal disease in terms of some adipocytokines and OS markers.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK) [114S823]en_US
dc.description.sponsorshipThis study was supported by the Scientific and Technological Research Council of Turkey (TUBITAK), (Project number 114S823).en_US
dc.identifier.doi10.1007/s00784-022-04854-7
dc.identifier.endpage2773en_US
dc.identifier.issn1432-6981
dc.identifier.issn1436-3771
dc.identifier.issue6en_US
dc.identifier.pmid36604342en_US
dc.identifier.scopus2-s2.0-85145674647en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage2763en_US
dc.identifier.urihttps://doi.org/10.1007/s00784-022-04854-7
dc.identifier.urihttps://hdl.handle.net/11616/101097
dc.identifier.volume27en_US
dc.identifier.wosWOS:000909185400002en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Heidelbergen_US
dc.relation.ispartofClinical Oral Investigationsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAdipocytokineen_US
dc.subjectNon-surgical periodontal therapyen_US
dc.subjectObesityen_US
dc.subjectOxidative stressen_US
dc.titleObesity as a modifying factor of periodontal therapy outcomes: local and systemic adipocytokines and oxidative stress markersen_US
dc.typeArticleen_US

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