Trimetazidine Increases Cell Survival and Inhibits the Activation of Inflammatory Response in Sodium Taurocholate-Induced Acute Pancreatitis

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dc.authoridDEMIRBAG, Ali E./0000-0003-3852-868X
dc.authoridErikci, Acelya/0000-0001-9149-9510
dc.authorwosidFırat, Tülin/A-8954-2016
dc.authorwosidTöre, Fatma/AAT-5652-2020
dc.authorwosidDEMIRBAG, Ali E./AAA-4186-2021
dc.authorwosidTore, Fatma/HJH-5460-2023
dc.authorwosidErikci, Acelya/I-8427-2013
dc.authorwosidErikci, Acelya/AAI-2965-2021
dc.contributor.authorIsik, Sevil
dc.contributor.authorSengul, Neriman
dc.contributor.authorTore, Fatma
dc.contributor.authorAydin, Cemalettin
dc.contributor.authorAslan, Acelya
dc.contributor.authorUcar, Gulberk
dc.contributor.authorFirat, Tulin
dc.date.accessioned2024-08-04T20:45:50Z
dc.date.available2024-08-04T20:45:50Z
dc.date.issued2017
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: To evaluate the therapeutic effects of trimetazidine (TMZ) in an experimental acute pancreatitis (AP) model induced with sodium taurocholate (STC). Summary of Background Data: At present, AP is considered a disease with no specific treatment. Preventing mitochondrial dysfunction in acinar cells may be an option for specific treatment of AP. TMZ is an anti-ischemic drug with anti-inflammatory, antioxidant, and mitochondrial modulatory effects. Methods: Rats were divided into 4 groups. AP was induced in the AP (n = 7) and AP + TMZ (n = 7) groups by an injection of 4% sodium taurocholate to the pancreatic duct. The sham (n = 6) and drug (n = 6) groups were designated as control groups. The AP + TMZ and drug groups were administered TMZ. Samples were taken at 72 hours, and histopathologic changes as well as biochemical parameters were analyzed. Results: Serum amylase, tissue myeloperoxidase activity, malondialdehyde levels, serum cytokine levels, and mast cell degranulation rates were elevated after induction of AP, whereas tissue antioxidant enzyme activities and cell viability rates [determined by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay] decreased. These parameters were found to be different in the AP group compared with those in all other groups (P < 0.05). A significant improvement of all parameters was achieved with the TMZ treatment of AP. Histologically, significant differences were found between the AP and AP + TMZ groups in terms of leukocyte infiltration, necrosis, and apoptotic cell counts. Conclusions: In this study, we demonstrated that TMZ treatment protected the mitochondrial function and prevented the activation of the inflammatory cascade in the sodium taurocholate-induced AP model.en_US
dc.identifier.doi10.9738/INTSURG-D-17-00122.1
dc.identifier.endpage551en_US
dc.identifier.issn0020-8868
dc.identifier.issue11-12en_US
dc.identifier.scopus2-s2.0-85063218261en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage542en_US
dc.identifier.urihttps://doi.org/10.9738/INTSURG-D-17-00122.1
dc.identifier.urihttps://hdl.handle.net/11616/98728
dc.identifier.volume102en_US
dc.identifier.wosWOS:000460124300010en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherInt College Of Surgeonsen_US
dc.relation.ispartofInternational Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAcute pancreatitisen_US
dc.subjectMitochondriaen_US
dc.subjectTrimetazidineen_US
dc.subjectMast cellen_US
dc.subjectOxidative stressen_US
dc.subjectExperimentalen_US
dc.titleTrimetazidine Increases Cell Survival and Inhibits the Activation of Inflammatory Response in Sodium Taurocholate-Induced Acute Pancreatitisen_US
dc.typeArticleen_US

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