Investigation of hepatitis B virus prevalence and reactivation frequency in malignancy patients administering chemotherapy

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dc.contributor.authorCengiz, Muhammet
dc.contributor.authorSeckin, Yuksel
dc.contributor.authorCagin, Yasir Furkan
dc.contributor.authorCengiz, Ayse Nuransoy
dc.date.accessioned2024-08-04T19:42:39Z
dc.date.available2024-08-04T19:42:39Z
dc.date.issued2021
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAim: This study aimed to investigate the frequency at which physicians test hepatitis B virus (HBV) serology before treatment and the rate of hepatitis B virus reactivation (HBVr) after treatment in patients undergoing chemotherapy (CT) due to a solid organ malignancy (SOM) or hematological malignancy (HM). Materials and Methods: Baseline clinical feature, HBV serology, and liver function test data for 1275 patients ? 18 years of age who underwent CT for the first time due to various SOMs and HMs from 2015-2017 were obtained from the database and retrospectively analyzed. HBV serology was studied in 296 (201 HM, 95 SOM) of the 1275 patients retrieved from the database. Results: The prevalence of HBV was 9.5% (121 patients). Only 49 (40.4%) HBV-positive patients had HBV DNA. Of those, 72 (59.5%) underwent prophylactic antiviral therapy. HBVr was detected in only 3 patients (1.5%), and all of those patients had HMs and were recommended oral antiviral therapy but did not. Conclusion: In patients with SOMs, the screening rates of HBV serology, as well as prophylaxis and follow-up HMs were extremely low. Therefore, these patients should be screened for HBV serology and prophylactic treatment should be given when necessary for HBVr.en_US
dc.identifier.doi10.5455/annalsmedres.2021.02.189
dc.identifier.endpage2064en_US
dc.identifier.issn2636-7688
dc.identifier.issue11en_US
dc.identifier.startpage2059en_US
dc.identifier.trdizinid482786en_US
dc.identifier.urihttps://doi.org/10.5455/annalsmedres.2021.02.189
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/482786
dc.identifier.urihttps://hdl.handle.net/11616/88552
dc.identifier.volume28en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofAnnals of Medical Researchen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleInvestigation of hepatitis B virus prevalence and reactivation frequency in malignancy patients administering chemotherapyen_US
dc.typeArticleen_US

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