Ninety Sixth-Hour Impact of Scalding Burns on End Organ Damage, Systemic Oxidative Stress, and Wound Healing in Rats Treated With Three Different Types of Dressings

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dc.authoridGÜRÜNLÜOĞLU, Kubilay/0000-0002-8315-1765
dc.authoridAkbulut, Sami/0000-0002-6864-7711
dc.authoridaslan, mehmet/0000-0001-5710-6592
dc.authoridGul, Semir/0000-0002-4668-9603
dc.authoridOZSOY, Eda Nur/0000-0003-4249-5024
dc.authoridTurkoz, Yusuf/0000-0001-5401-0720
dc.authoridGURUNLUOGLU, SEMRA/0000-0002-9737-859X
dc.authorwosidGÜRÜNLÜOĞLU, Kubilay/AAO-5631-2020
dc.authorwosidAkbulut, Sami/L-9568-2014
dc.contributor.authorAslan, Mehmet
dc.contributor.authorGul, Mehmet
dc.contributor.authorUremis, Nuray
dc.contributor.authorAkbulut, Sami
dc.contributor.authorGurunluoglu, Semra
dc.contributor.authorOzsoy, Eda Nur
dc.contributor.authorTurkoz, Yusuf
dc.date.accessioned2024-08-04T20:55:59Z
dc.date.available2024-08-04T20:55:59Z
dc.date.issued2024
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIn this study, we investigated the effects of 3 different burn dressing treatments, including experimental, silver, and modern dressing materials, on systemic oxidative stress in rats with severe scald burns within the first 96 h. The rats were divided into five groups: a burn group (n = 10), a polylactic membrane group (n = 10), a silver sulfadiazine group (n = 10), a curcumin group (n = 10), and a control group (n = 10), consisting of equal numbers of female and male rats. In the first 4 groups, 30% of the rats' total body surface area was scalded at 95 degrees C. The burn group was not treated. Each group was treated with group-name dressing material. The control group was neither treated nor burned. The rats were sacrificed, and blood and tissue samples were obtained at the 96th hour when severe effects of oxidative stress developed postburns. Systemic inflammatory biomarkers and oxidative stress parameters were examined. In addition, apoptosis and organ damage in liver, kidney, lung, and skin tissues were evaluated biochemically and histopathologically. When the parameters were statistically analyzed, we found that the systemic levels of oxidative stress and inflammatory damage to liver, kidney, and lung tissues were lower in the 3 treated groups than in the burn group. We believe that the dressing material's efficacy in the treatment of severe burns may be dependent on its ability to combat oxidative stress and inflammation.en_US
dc.description.sponsorshipUniversity's Scientific Research Project Coordination Unit; Inonu University Scientific Research Project Coordination Uniten_US
dc.description.sponsorshipWe would like to thank Inonu University Scientific Research Project Coordination Unit for their contributions.en_US
dc.identifier.doi10.1093/jbcr/irad191
dc.identifier.endpage743en_US
dc.identifier.issn1559-047X
dc.identifier.issn1559-0488
dc.identifier.issue3en_US
dc.identifier.pmid38079377en_US
dc.identifier.scopus2-s2.0-85192681842en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage733en_US
dc.identifier.urihttps://doi.org/10.1093/jbcr/irad191
dc.identifier.urihttps://hdl.handle.net/11616/101984
dc.identifier.volume45en_US
dc.identifier.wosWOS:001197488400001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherOxford Univ Pressen_US
dc.relation.ispartofJournal of Burn Care & Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectburnen_US
dc.subjectcurcuminen_US
dc.subjectoxidative stressen_US
dc.subjectpolylactic membraneen_US
dc.subjectsilver sulfadiazineen_US
dc.subjectsystemic inflammationen_US
dc.titleNinety Sixth-Hour Impact of Scalding Burns on End Organ Damage, Systemic Oxidative Stress, and Wound Healing in Rats Treated With Three Different Types of Dressingsen_US
dc.typeArticleen_US

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