Predictive and Prognostic Factors in Ovarian and Uterine Carcinosarcomas

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dc.authoridTanriverdi, Ozgur/0000-0002-0598-7284
dc.authoridSevinç, Alper/0000-0002-0499-8918
dc.authoridCicin, Irfan/0000-0002-7584-3868
dc.authoridÖksüzoğlu Çakmak, Ömür Berna/0000-0002-2756-8646
dc.authoridHacioglu, Bekir/0000-0001-8490-3239
dc.authoridaksoy, asude/0000-0002-5609-9658
dc.authorwosidDurnalı, Ayşe/ABC-2229-2021
dc.authorwosidTanriverdi, Ozgur/M-2172-2015
dc.authorwosidErdogan, Bulent/AAA-9781-2021
dc.authorwosidmenekşe, serkan/HNP-3265-2023
dc.authorwosidSevinç, Alper/KPA-4519-2024
dc.authorwosidSevinc, Alper/KFQ-6440-2024
dc.authorwosidCicin, Irfan/AAQ-5575-2020
dc.contributor.authorCicin, Irfan
dc.contributor.authorOzatli, Tahsin
dc.contributor.authorTurkmen, Esma
dc.contributor.authorOzturk, Turkan
dc.contributor.authorOzcelik, Melike
dc.contributor.authorCabuk, Devrim
dc.contributor.authorGokdurnali, Ayse
dc.date.accessioned2024-08-04T20:42:41Z
dc.date.available2024-08-04T20:42:41Z
dc.date.issued2016
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: Prognostic factors and the standard treatment approach for gynaecological carcinosarcomas have not yet been clearly defined. Although carcinosarcomas are more aggressive than pure epithelial tumours, they are treated similarly. Serous/clear cell and endometrioid components may be predictive factors for the efficacy of adjuvant chemotherapy (CT) or radiotherapy (RT) or RT in patients with uterine and ovarian carcinosarcomas. Heterologous carcinosarcomas may benefit more from adjuvant CT. Aims: We aimed to define the prognostic and predictive factors associated with treatment options in ovarian (OCS) and uterine carcinosarcoma (UCS). Study Design: Retrospective cross-sectional study Methods: We retrospectively reviewed the medical records of patients with ovarian and uterine carcinosarcoma from 2000 to 2013, and 127 women were included in this study (24 ovarian and 103 uterine). Patients admitted to seventeen oncology centres in Turkey between 2000 and December 2013 with a histologically proven diagnosis of uterine carcinosarcoma with FIGO 2009 stage I-III and patients with sufficient data obtained from well-kept medical records were included in this study. Stage IV tumours were excluded. The patient records were retrospectively reviewed. Data from 104 patients were evaluated for this study. Results: Age (>= 70 years) was a poor prognostic factor for UCS (p=0.036). Pelvic +/- para aortic lymph node dissection did not affect overall survival (OS) (p=0.35). Macroscopic residual disease was related with OS (p<0.01). The median OS was significantly longer in stage I-II patients than stage III patients (p=0.03). Adjuvant treatment improved OS (p=0.013). Adjuvant radiotherapy tended to increase the median OS (p=0.075). However, this tendency was observed in UCS (p=0.08) rather than OCS (p=0.6). Adjuvant chemotherapy had no effect on OS (p=0.15). Adjuvant radiotherapy significantly prolonged the median OS in patients with endometrioid component (p=0.034). A serous/clear cell component was a negative prognostic factor (p=0.035). Patients with serous/clear cell histology for whom adjuvant chemotherapy was applied had significantly longer OS (p=0.019), and there was no beneficial effect of adjuvant radiotherapy (p=0.4). Adjuvant chemotherapy was effective in heterologous tumours (p=0.026). In multivariate analysis, the stage and chemotherapy were prognostic factors for all patients. Age was an independent prognostic factor for UCS. However, serous/clear cell histology and radiotherapy tended to be significant prognostic factors. Conclusion: The primary location, the histological type of sarcomatous and the epithelial component may be predictive factors for the efficacy of chemotherapy or radiotherapy in UCS and OCS.en_US
dc.identifier.doi10.5152/balkanmedj.2016.151268
dc.identifier.endpage524en_US
dc.identifier.issn2146-3123
dc.identifier.issn2146-3131
dc.identifier.issue5en_US
dc.identifier.pmid27761279en_US
dc.identifier.scopus2-s2.0-84989284795en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage517en_US
dc.identifier.urihttps://doi.org/10.5152/balkanmedj.2016.151268
dc.identifier.urihttps://hdl.handle.net/11616/97517
dc.identifier.volume33en_US
dc.identifier.wosWOS:000384744100006en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherGalenos Publ Houseen_US
dc.relation.ispartofBalkan Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCarcinosarcomaen_US
dc.subjectovaryen_US
dc.subjectuterineen_US
dc.subjectpredictive factorsen_US
dc.subjectprognostic factorsen_US
dc.titlePredictive and Prognostic Factors in Ovarian and Uterine Carcinosarcomasen_US
dc.typeArticleen_US

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