N-terminal pro-B-type natriuretic peptide as a marker of blunt cardiac contusion in trauma

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dc.authoridOZUCELIK, Dogac Niyazi/0000-0002-7752-0667
dc.authoridOkuturlar, Yildiz/0000-0002-1994-0014
dc.authoridYucel, Neslihan/0000-0001-5845-2614
dc.authoridDoğan, H/0000-0003-4751-030X
dc.authorwosidOZUCELIK, Dogac Niyazi/JJF-1751-2023
dc.authorwosidOkuturlar, Yildiz/X-3647-2018
dc.authorwosidOZUCELIK, DOGAC NIYAZI/JCE-0651-2023
dc.authorwosidYucel, Neslihan/ABI-3412-2020
dc.authorwosidDoğan, H/AGL-2540-2022
dc.contributor.authorDogan, Halil
dc.contributor.authorSarikaya, Sezgin
dc.contributor.authorNeijmann, Sebnem Tekin
dc.contributor.authorUysal, Emin
dc.contributor.authorYucel, Neslihan
dc.contributor.authorOzucelik, Dogac Niyazi
dc.contributor.authorOkuturlar, Yildiz
dc.date.accessioned2024-08-04T20:40:23Z
dc.date.available2024-08-04T20:40:23Z
dc.date.issued2015
dc.departmentİnönü Üniversitesien_US
dc.description.abstractCardiac contusion is usually caused by blunt chest trauma and, although it is potentially a life-threatening condition, the diagnosis of a myocardial contusion is difficult because of non-specific symptoms and the lack of an ideal test to detect myocardial damage. Cardiac enzymes, such as creatine kinase (CK), creatine kinase MB fraction (CK-MB), cardiac troponin I (cTn-I), and cardiac troponin T (cTn-T) were used in previous studies to demonstrate the blunt cardiac contusion (BCC). Each of these diagnostic tests alone is not effective for diagnosis of BCC. The aim of this study was to investigate the serum heart-type fatty acid binding protein (h-FABP), N-terminal pro-B-type natriuretic peptide (NT-proBNP), CK, CK-MB, and cTn-I levels as a marker of BCC in blunt chest trauma in rats. The eighteen Wistar albino rats were randomly allocated to two groups; group I (control) (n=8) and group II (blunt chest trauma) (n=10). Isolated BCC was induced by the method described by Raghavendran et al. (2005). All rats were observed in their cages and blood samples were collected after five hours of trauma for the analysis of serum hFABP, NT-pro BNP, CK, CK-MB, and cTn-I levels. The mean serum NT-pro BNP was significantly different between group I and II (10.3 +/- 2.10 ng/L versus 15.4 +/- 3.68 ng/L, respectively; P=0.0001). NT-pro BNP level >13 ng/ml had a sensitivity of 87.5%, a specificity of 70%, a positive predictive value of 70%, and a negative predictive value of 87.5% for predicting blunt chest trauma (area under curve was 0.794 and P=0.037). There was no significant difference between two groups in serum h-FABP, CK, CK-MB and c Tn-I levels. A relation between NT-Pro BNP and BCC was shown in this study. Serum NT-proBNP levels significantly increased with BCC after 5 hours of the blunt chest trauma. The use of NT-proBNP as an adjunct to other diagnostic tests, such as troponins, electrocardiography (ECG), chest x-ray and echocardiogram may be beneficial for diagnosis of BCC.en_US
dc.identifier.endpage6792en_US
dc.identifier.issn1936-2625
dc.identifier.issue6en_US
dc.identifier.pmid26261563en_US
dc.identifier.scopus2-s2.0-84938630516en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage6786en_US
dc.identifier.urihttps://hdl.handle.net/11616/96889
dc.identifier.volume8en_US
dc.identifier.wosWOS:000359277700086en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherE-Century Publishing Corpen_US
dc.relation.ispartofInternational Journal of Clinical and Experimental Pathologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNT-Pro BNPen_US
dc.subjecth-FABPen_US
dc.subjectblunt chest traumaen_US
dc.subjectblunt cardiac contusionen_US
dc.subjecttraumaen_US
dc.subjectemergency medicineen_US
dc.titleN-terminal pro-B-type natriuretic peptide as a marker of blunt cardiac contusion in traumaen_US
dc.typeArticleen_US

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