Effects of papaverine on healing of colonic anastomosis in rats

Basit Öğe Kaydı
dc.authoridBasceken, Salim Ilksen/0000-0002-0918-3208
dc.authoridSevim, Yusuf/0000-0002-2708-1598
dc.authoridÇakmak, Atıl/0000-0003-2386-6213
dc.authoridAkyol, Cihangir/0000-0002-3941-5268
dc.authorwosidCicek, Egemen/ABH-3190-2020
dc.authorwosidAkyol, Cihangir/AFC-8758-2022
dc.authorwosidBasceken, Salim Ilksen/T-4301-2018
dc.authorwosidSevim, Yusuf/J-2366-2014
dc.authorwosidcicek, egemen/HJY-0590-2023
dc.authorwosidgenc, volkan/AAQ-3865-2020
dc.authorwosidÇakmak, Atıl/AAP-9690-2020
dc.contributor.authorBasceken, Salim Ilksen
dc.contributor.authorSevim, Yusuf
dc.contributor.authorAkyol, Cihangir
dc.contributor.authorCicek, Egemen
dc.contributor.authorAydin, Ferit
dc.contributor.authorKocaay, Akin Firat
dc.contributor.authorPasaoglu, Ozge Tugce
dc.date.accessioned2024-08-04T20:43:12Z
dc.date.available2024-08-04T20:43:12Z
dc.date.issued2017
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground Anastomotic leak is the most devastating complication after colorectal surgery, and the blood supply is a very important factor in anastomotic healing. Papaverine is a vasodilatory and antispasmodic agent which has been used in many ischemic conditions because of its potentially protective effects. The aim of this study is to investigate the effects of papaverine on healing colon anastomosis. Methods Forty 8- to 10-week-old female Wistar Albino rats were used in this study. Rats were randomized into 4 groups: control group; ischemia-reperfusion and anastomosis group; ischemia-reperfusion and anastomosis + intraperitoneal one dose papaverine group; and ischemia-reperfusion and anastomosis + intraperitoneal daily (10 days) papaverine group. Anastomotic bursting pressures, the hydroxyproline measurements and macroscopic adhesion gradings were evaluated. Results There was a significant difference between papaverine-administered groups and ischemia-reperfusion and anastomosis group for anastomotic bursting pressures, hydroxyproline measurements and macroscopic adhesion grading (p < 0.05). Conclusion In the rat model, papaverine had a favorable effect on anastomotic healing.en_US
dc.identifier.doi10.1007/s10353-017-0481-1
dc.identifier.endpage164en_US
dc.identifier.issn1682-8631
dc.identifier.issn1682-4016
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85020740758en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage158en_US
dc.identifier.urihttps://doi.org/10.1007/s10353-017-0481-1
dc.identifier.urihttps://hdl.handle.net/11616/97859
dc.identifier.volume49en_US
dc.identifier.wosWOS:000407245900002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSpringer Wienen_US
dc.relation.ispartofEuropean Surgery-Acta Chirurgica Austriacaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectIschemia-reperfusion injuryen_US
dc.subjectAnastomotic leaken_US
dc.subjectPapaverineen_US
dc.titleEffects of papaverine on healing of colonic anastomosis in ratsen_US
dc.typeArticleen_US

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