Synthesis of 2-(2,3,4-trimethoxyphenyl)-1-(substituted-phenyl)acrylonitriles: in vitro anticancer activity against MCF-7, PC-3 and A2780 cancer cell lines

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dc.authoridOzen, Furkan/0000-0003-1178-1167
dc.authoridSandal, Suleyman/0000-0002-8916-3329
dc.authoridKORAN, KENAN/0000-0002-2218-7211
dc.authoridGORGULU, AHMET/0000-0002-7549-1524
dc.authoridTekin, Suat/0000-0002-2757-1802
dc.authoridGorgulu, Ahmet Orhan/0000-0003-0632-4834
dc.authorwosidOzen, Furkan/IAQ-9356-2023
dc.authorwosidTekin, Suat/AAG-1440-2021
dc.authorwosidSandal, Suleyman/AAA-6388-2021
dc.authorwosidKORAN, KENAN/L-6764-2016
dc.authorwosidGörgülü, Ahmet Orhan/AAQ-4282-2021
dc.authorwosidGORGULU, AHMET/KBA-2787-2024
dc.authorwosidTekin, Suat/IZD-9868-2023
dc.contributor.authorOzen, Furkan
dc.contributor.authorTekin, Suat
dc.contributor.authorKoran, Kenan
dc.contributor.authorSandal, Suleyman
dc.contributor.authorGorgulu, Ahmet Orhan
dc.date.accessioned2024-08-04T20:41:45Z
dc.date.available2024-08-04T20:41:45Z
dc.date.issued2016
dc.departmentİnönü Üniversitesien_US
dc.description.abstractA series of 2-(2,3,4-trimethoxyphenyl)-1-(substituted-phenyl)acrylonitrile (2-9) were designed and synthesized to develop new cancer drugs. The structures of synthesized compounds 2-9 were described by using melting point, mass (MALDI-TOF-MS), FT-IR, elemental analysis, H-1, C-13, C-13-APT and 2D NMR spectroscopy. The in vitro anticancer activities of 2-9 against human breast cancer (MCF-7), human prostate cancer (PC-3) and human ovarian cancer cells (A2780) were investigated by [3-(4,5-dimethylthiazol)-2-yl]-2,5-diphenyl-2H-tetrazolium bromide] (MTT) assay method. Additionally, the LogIC(50) values of these compounds on A2780, MCF-7 and PC-3 cell lines were calculated by using inhibition % values by the GraphPad Prism 6 program on a computer. The results indicated that these compounds have high anticancer activity against MCF-7, PC-3 and A2780 cell lines (especially A2780 cell lines, p < 0.05).en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK) [110T652]; TUBITAKen_US
dc.description.sponsorshipThis research was supported financially by The Scientific and Technological Research Council of Turkey (TUBITAK) (Project Number: 110T652). The authors are grateful to the Research Fund of the TUBITAK for their support.en_US
dc.identifier.doi10.1007/s11164-016-2562-3
dc.identifier.endpage7805en_US
dc.identifier.issn0922-6168
dc.identifier.issn1568-5675
dc.identifier.issue12en_US
dc.identifier.scopus2-s2.0-84966335572en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage7793en_US
dc.identifier.urihttps://doi.org/10.1007/s11164-016-2562-3
dc.identifier.urihttps://hdl.handle.net/11616/97309
dc.identifier.volume42en_US
dc.identifier.wosWOS:000388141100002en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofResearch on Chemical Intermediatesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPhenylacrylonitrile derivativesen_US
dc.subjectHuman ovarian cancer cellen_US
dc.subjectMCF-7en_US
dc.subjectAnticancer evaluationen_US
dc.subjectPC-3en_US
dc.titleSynthesis of 2-(2,3,4-trimethoxyphenyl)-1-(substituted-phenyl)acrylonitriles: in vitro anticancer activity against MCF-7, PC-3 and A2780 cancer cell linesen_US
dc.typeArticleen_US

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