Patients with hematologic cancers are more vulnerable to COVID-19 compared to patients with solid cancers

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dc.authoridHacıbekiroğlu, Tuba/0000-0003-1814-5972
dc.authoridBaşcı, Semih/0000-0003-4304-9245
dc.authoridYigenoglu, Tugce/0000-0001-9962-8882
dc.authoridDogu, Mehmet Hilmi/0000-0001-7237-2637
dc.authoridErkurt, Mehmet Ali/0000-0002-3285-417X
dc.authoridBirinci, Suayip/0000-0001-8104-6198
dc.authoridBasturk, Abdulkadir/0000-0003-1864-0316
dc.authorwosidHacıbekiroğlu, Tuba/ABH-2380-2020
dc.authorwosidBaşcı, Semih/AAB-4823-2021
dc.authorwosidYigenoglu, Tugce/ABF-6595-2021
dc.authorwosidDogu, Mehmet Hilmi/W-2255-2017
dc.authorwosidKorkmaz, Serdal/IST-3736-2023
dc.authorwosidErkurt, Mehmet Ali/ABI-7232-2020
dc.authorwosidBirinci, Suayip/JFJ-4049-2023
dc.contributor.authorBasci, Semih
dc.contributor.authorAta, Naim
dc.contributor.authorAltuntas, Fevzi
dc.contributor.authorYigenoglu, Tugce Nur
dc.contributor.authorDal, Mehmet Sinan
dc.contributor.authorKorkmaz, Serdal
dc.contributor.authorNamdaroglu, Sinem
dc.date.accessioned2024-08-04T20:50:18Z
dc.date.available2024-08-04T20:50:18Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractPrevious studies reported that COVID-19 patients with cancer had higher rates of severe events such as intensive care unit (ICU) admission, mechanical ventilation (MV) assistance, and death during the COVID-19 course compared to the general population. However, no randomized study compared the clinical course of COVID-19 in patients with hematologic cancers to patients with solid cancers. Thus, in this study, we intend to reveal the outcome of COVID-19 in hematologic cancer patients and compare their outcomes with COVID-19 patients with solid cancers. The data of 926 laboratory-confirmed COVID-19 patients, including 463 hematologic cancer patients and an age-gender paired cohort of 463 solid cancer patients, were investigated retrospectively. The frequencies of severe and critical disease, hospital and ICU admission, MV assistance were significantly higher in hematologic cancer patients compared with the solid cancer patients (p = 0.001, p = 0.045, p = 0.001, and p = 0.001, respectively). The hospital stay was longer in patients with hematologic cancers (p = 0.001); however, the median ICU stay was 6 days in both groups. The case fatality rate (CFR) was 14.9% in patients with hematologic cancers, and it was 4.8% in patients with solid cancers, and there was a statistically significant difference regarding CFR between groups (p = 0.001). Our study revealed that COVID-19 patients with hematologic cancers have a more aggressive course of COVID-19 and have higher CFR compared to COVID-19 patients with solid cancers and support the increased susceptibility of patients with hematologic cancers during the outbreak.en_US
dc.identifier.doi10.1007/s11739-021-02784-y
dc.identifier.endpage139en_US
dc.identifier.issn1828-0447
dc.identifier.issn1970-9366
dc.identifier.issue1en_US
dc.identifier.pmid34110562en_US
dc.identifier.scopus2-s2.0-85107801967en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage135en_US
dc.identifier.urihttps://doi.org/10.1007/s11739-021-02784-y
dc.identifier.urihttps://hdl.handle.net/11616/99983
dc.identifier.volume17en_US
dc.identifier.wosWOS:000659852100004en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer-Verlag Italia Srlen_US
dc.relation.ispartofInternal and Emergency Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCOVID-19en_US
dc.subjectSARS-CoV-2en_US
dc.subjectHematologic canceren_US
dc.subjectSolid tumoren_US
dc.titlePatients with hematologic cancers are more vulnerable to COVID-19 compared to patients with solid cancersen_US
dc.typeArticleen_US

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