Serum leptin concentration is increased in patients with Behcet's syndrome and is correlated with disease activity

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dc.authoridOTLU, BARIS/0000-0002-6220-0521
dc.authoridKırtak, Necmettin/0000-0002-3789-0612
dc.authorwosidOTLU, BARIS/ABI-5532-2020
dc.authorwosidEvereklioğlu, Cem/A-5370-2018
dc.authorwosidKırtak, Necmettin/AAH-4469-2020
dc.contributor.authorEvereklioglu, C
dc.contributor.authorInalöz, HS
dc.contributor.authorKirtak, N
dc.contributor.authorDoganay, S
dc.contributor.authorBülbül, M
dc.contributor.authorOtlu, B
dc.contributor.authorÖzerol, E
dc.date.accessioned2024-08-04T20:13:08Z
dc.date.available2024-08-04T20:13:08Z
dc.date.issued2002
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground Behcet's syndrome is a systemic, relapsing immuno-inflammatory disease with a generalized vasculitis of the microvasculature endothelial dysfunction. Leptin, a recently discovered neuroendocrine hormone, is a metabolic peptide that appears to be involved. Serum proinflammatory cytokines upregulate leptin levels and leptin itself directly induces nitric oxide production from endothelial cells with its specific receptors. Objectives To detect changes of serum leptin concentrations in patients with Behcet's syndrome compared with age- and sex-matched healthy volunteers by using enzyme-linked immunosorbent assay. We also investigated whether disease activity or the duration of Behcet's syndrome correlates with leptin concentration. Methods Thirty-five consecutive patients with Behcet's syndrome (41.2 +/- 8.4 years, 16 male, 19 female) and 20 age- and sex-matched healthy control subjects (40.4 +/- 10.91 years, nine male, 11 female) were included in this study. The body mass index (BMI) [weight (kg) height(-1) (m(2) )] was calculated for subjects at study enrolment. We measured serum leptin with a leptin enzyme immunoassay kit, and acute-phase reactants, including erythrocyte sedimentation rate, alpha(1) -antitrypsin, alpha(2) -macroglobulin and neutrophil count. The Mann-Whitney U -test was used for statistical analysis and P < 0.05 was considered significant. Values were expressed as mean +/- SD. Results The gender ratio, age and BMI were not substantially different among Behcet's patients and controls. The mean serum leptin concentrations in patients with Behcet's syndrome (16.8 +/- 7.49 ng mL(-1) ) were significantly (P < 0.001) higher than in healthy control volunteers (7.5 +/- 2.77 ng mL(-1) ). Active Behcet's patients had significantly (P = 0.001) higher leptin concentrations (20.5 +/- 7.99 ng mL(-1) ) when compared with patients in inactive periods (12.8 +/- 4.43 ng mL(-1) ). In addition, patients with longer disease duration (mean, 20.1 +/- 5.15 years) had also significantly (P = 0.013) higher leptin concentrations (20.2 +/- 8.52 ng mL(-1) ) than those with shorter disease duration (13.4 +/- 4.52 ng mL(-1) ) (mean, 7.4 +/- 3.29 years). All acute-phase reaction parameters were found to be significantly (for each, P < 0.01) increased in active disease. Conclusions Leptinmay have a role in modulating endothelial function and may be involved in mechanisms for vessel endothelium repair, during an exacerbation as well as in chronic disease.en_US
dc.identifier.doi10.1046/j.1365-2133.2002.04703.x
dc.identifier.endpage336en_US
dc.identifier.issn0007-0963
dc.identifier.issue2en_US
dc.identifier.pmid12174107en_US
dc.identifier.scopus2-s2.0-0036379507en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage331en_US
dc.identifier.urihttps://doi.org/10.1046/j.1365-2133.2002.04703.x
dc.identifier.urihttps://hdl.handle.net/11616/93406
dc.identifier.volume147en_US
dc.identifier.wosWOS:000177362600019en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBlackwell Publishing Ltden_US
dc.relation.ispartofBritish Journal of Dermatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBehcet's syndromeen_US
dc.subjectchronicityen_US
dc.subjectdisease activityen_US
dc.subjectleptinen_US
dc.titleSerum leptin concentration is increased in patients with Behcet's syndrome and is correlated with disease activityen_US
dc.typeArticleen_US

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