Evaluation of metabolite changes in visual cortex in diabetic retinopathy by MR-Spectroscopy

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dc.authoridBozgul, Pembegul/0000-0002-9427-3610
dc.authorwosidBozgul, Pembegul/AAQ-4951-2020
dc.contributor.authorOzsoy, Ercan
dc.contributor.authorDoganay, Selim
dc.contributor.authorDogan, Metin
dc.contributor.authorAlkan, Alpay
dc.contributor.authorFirat, Penpe Gul
dc.date.accessioned2024-08-04T20:35:55Z
dc.date.available2024-08-04T20:35:55Z
dc.date.issued2012
dc.departmentİnönü Üniversitesien_US
dc.description.abstractPurpose: To evaluate metabolite changes in the visual cortex of diabetic patients with nonproliferative or proliferative diabetic retinopathy by Magnetic Resonance Spectroscopy (MRS). Materials and Methods: 15 normal subjects (group 1), 15 patients with diabetes who did not have diabetic retinopathy (group 2), 15 patients with nonproliferative diabetic retinopathy (NPDR) (group 3), and 15 patients with proliferative diabetic retinopathy (PDR) (group 4) were included in the study. Furthermore, diabetic patients were divided into two groups according to HbA1c levels (Group A: 20 patients, HbA1c <8%; Group B: 20 patients, HbA1c >8%). In all cases' left visual cortex, amounts of N-acetyl-aspartate (NAA), choline (Cho), and creatine (Cr) were measured by MRS. NAA/Cr, Cho/Cr, and NAA/Cho ratios were calculated. Furthermore, all cases' complete blood count (CBC) and biochemical parameters were evaluated. Results: There was no statistically significant difference for NAA/Cr, Cho/Cr, and NAA/Cho ratios between groups 1. 2, 3, and 4 (P>0.05). However there was a statistically significant difference for NAA/Cr and NAA/Cho ratios between groups A and B (P<0.05). There was no statistically significant difference for Cho/Cr ratio between groups A and B (P>0.05). Conclusion: Although NAA/Cr and NAA/Cho ratios decrease in the visual cortex while diabetic retinopathy progresses, these decreases are not statistically significant. While HbA1c levels increase, the NAA concentration decreases in the visual cortex which indicates neuronal loss. The metabolite changes in the visual cortex are associated with acute events rather than chronic. (c) 2012 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/j.jdiacomp.2012.03.007
dc.identifier.endpage245en_US
dc.identifier.issn1056-8727
dc.identifier.issn1873-460X
dc.identifier.issue3en_US
dc.identifier.pmid22512974en_US
dc.identifier.scopus2-s2.0-84861642044en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage241en_US
dc.identifier.urihttps://doi.org/10.1016/j.jdiacomp.2012.03.007
dc.identifier.urihttps://hdl.handle.net/11616/95672
dc.identifier.volume26en_US
dc.identifier.wosWOS:000305362500016en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofJournal of Diabetes and Its Complicationsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDiabetic retinopathyen_US
dc.subjectMR spectroscopyen_US
dc.titleEvaluation of metabolite changes in visual cortex in diabetic retinopathy by MR-Spectroscopyen_US
dc.typeArticleen_US

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