Protective role of intratympanic nigella sativa oil against gentamicin induced hearing loss

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dc.authoridAtas, Ahmet/0000-0002-8673-6793
dc.authoridatas, ahmet/0000-0002-8673-6793
dc.authoridGül, Mehmet/0000-0002-1374-0783
dc.authoridEdizer, Deniz Tuna/0000-0003-4448-1881
dc.authoridKARA, Eyyup/0000-0002-4015-4560
dc.authoridSENKAYA, DUYGU/0000-0002-8484-4846
dc.authorwosidEdizer, Deniz T/C-8812-2019
dc.authorwosidAtas, Ahmet/ABA-9893-2020
dc.authorwosidatas, ahmet/AAS-9417-2020
dc.authorwosidGül, Mehmet/ABI-6336-2020
dc.authorwosidEdizer, Deniz Tuna/GWQ-5748-2022
dc.authorwosidKARA, Eyyup/C-9766-2019
dc.authorwosidAtas, Ahmet/D-4190-2019
dc.contributor.authorEdizer, Deniz Tuna
dc.contributor.authorYigit, Ozgur
dc.contributor.authorCinar, Zehra
dc.contributor.authorGul, Mehmet
dc.contributor.authorKara, Eyyup
dc.contributor.authorYigitcan, Birgul
dc.contributor.authorHayir, Duygu
dc.date.accessioned2024-08-04T20:43:04Z
dc.date.available2024-08-04T20:43:04Z
dc.date.issued2017
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: Aminoglycosides, used to combat with life-threatening infections, have a substantial risk of hearing loss. Nigella sativa is an annual herbaceous plant and used for treatment of many diseases for ages. We aimed to investigate the protective role of intratympanic nigella sativa oil against gentamicin induced hearing loss in an animal model. Methods and materials: Twenty eight guinea pigs were randomly divided into four groups: i-control, ii-Intratympanic nigella sativa oil (IT-NSO), Intraperitoneal gentamicin (IP-G) and iv- Intraperitoneal gentamicin and intratympanic nigella sativa oil (IP-G + IT-NSO). Preoperative and postoperative hearing thresholds were determined with auditory brainstem response with click and 8 kHz tone-burst stimuli. Histological analysis of the cochlea specimens were performed under light microscope. Semiquantitative grading of the histological findings was carried out and compared between the groups. Results: Highest posttreatment hearing thresholds were detected in IP-G group. Posttreatment mean hearing threshold of the IP-G group with click stimulus was significantly higher than the IP-G + IT-NSO group (p = 0.004). whereas the difference was not significant with 8 kHz tone-burst stimulus (p = 0.137). Both IP-G and IP-G + IT-NSO groups had significantly higher hearing thresholds compared to control and IT-NSO groups (p > 0.05). Histological examination of the control and IT-NSO groups demonstrated normal appearance of cochlear nerve, stria vascularis and organ of Corti. IP-G group showed the most severe histological alterations including hydropic and vacuolar degenerations, hair cell damage and deformation of the basilar mambrane. Histological evidence of damage was significantly reduced in IP- G + IT-NSO group compared to IP-G group. Conclusion: Addition of intratympanic NSO to systemic gentamicin was demonstrated to have beneficial effects in hearing thresholds which was supported by histological findings. (C) 2017 Elsevier B.V. All rights reserved.en_US
dc.description.sponsorshipIstanbul Training and Research Hospital, Committee of Education and Planning [821 - 2013]en_US
dc.description.sponsorshipThis work was supported by Istanbul Training and Research Hospital, Committee of Education and Planning (821 - 2013).en_US
dc.identifier.doi10.1016/j.ijporl.2017.03.034
dc.identifier.endpage88en_US
dc.identifier.issn0165-5876
dc.identifier.issn1872-8464
dc.identifier.pmid28483257en_US
dc.identifier.scopus2-s2.0-85016995719en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage83en_US
dc.identifier.urihttps://doi.org/10.1016/j.ijporl.2017.03.034
dc.identifier.urihttps://hdl.handle.net/11616/97773
dc.identifier.volume97en_US
dc.identifier.wosWOS:000403730300015en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Ireland Ltden_US
dc.relation.ispartofInternational Journal of Pediatric Otorhinolaryngologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNigella sativaen_US
dc.subjectGentamicinen_US
dc.subjectHearing lossen_US
dc.subjectIntratympanicen_US
dc.titleProtective role of intratympanic nigella sativa oil against gentamicin induced hearing lossen_US
dc.typeArticleen_US

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