Biological aspects of HCC
Küçük Resim Yok
Tarih
2021
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Springer International Publishing
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Much has been published on experimental chemical hepatocarcinogenesis, but much less on experimental viral hepatocarcinogenesis. Furthermore, animal models for clinical HCC are typically missing one important component or other of the human disease, such as PVT. Despite this, much is understood about hepatocarcinogenic mechanisms and the biological principles underlying many clinical phenotypic HCC features. These include recent understanding of the importance of tumor microenvironment and the inflammatory context, immune signaling within the liver, cell growth and signaling pathways, resistance to cytotoxic chemotherapy as an inherent HCC property, the significance of vitamin K through understanding of the HCC biomarker, DCP, and the increasing importance of circulating tumor cells and DNA as a "liquid" minimally invasive biopsy. © The Author(s), under exclusive license to Springer Nature Switzerland AG 2021. All rights reserved.
Açıklama
Anahtar Kelimeler
Biomarkers, Drug resistance, Etiology, Growth, Inflammation, Liquid biopsy, Microenvironment, Platelets, Vascular characteristics
Kaynak
Liver Cancer in the Middle East
WoS Q Değeri
Scopus Q Değeri
N/A
