A Novel Ag-N-Heterocyclic Carbene Complex Bearing the Hydroxyethyl Ligand: Synthesis, Characterization, Crystal and Spectral Structures and Bioactivity Properties

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dc.authoridAktaş, Aydın/0000-0001-8496-6782
dc.authoridGulcin, ilhami/0000-0001-5993-1668
dc.authoridTaslimi, Parham/0000-0002-3171-0633
dc.authorwosidAktaş, Aydın/J-6194-2019
dc.authorwosidBarut Celepci, Duygu/M-6189-2017
dc.authorwosidTaslimi, Parham/AAL-2788-2020
dc.authorwosidGök, Yetkin/AAA-5669-2021
dc.authorwosidGulcin, ilhami/F-1428-2014
dc.contributor.authorAktas, Aydin
dc.contributor.authorCelepci, Duygu
dc.contributor.authorGok, Yetkin
dc.contributor.authorTaslimi, Parham
dc.contributor.authorAkincioglu, Hulya
dc.contributor.authorGulcin, Ilhami
dc.date.accessioned2024-08-04T20:47:12Z
dc.date.available2024-08-04T20:47:12Z
dc.date.issued2020
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIn this study, a novel silver N-heterocyclic carbene (Ag-NHC) complex bearing hydroxyethyl substituent has been synthesized from the hydroxyethyl-substituted benzimidazolium salt and silver oxide by using in-situ deprotonation method. A structure of the Ag-NHC complex was characterized by using UV-Vis, FTIR, H-1-NMR and C-13-NMR spectroscopies and elemental analysis techniques. Also, the crystal structure of the novel complex was determined by single-crystal X-ray diffraction method. In this paper, compound 1 showed excellent inhibitory effects against some metabolic enzymes. This complex had Ki of 1.14 0.26 mu M against human carbonic anhydrase I (hCA I), 1.88 +/- 0.20 mu M against human carbonic anhydrase II (hCA I), and 10.75 +/- 2.47 mu M against alpha-glycosidase, respectively. On the other hand, the Ki value was found as 25.32 +/- 3.76 mu M against acetylcholinesterase (AChE) and 41.31 +/- 7.42 mu M against butyrylcholinesterase (BChE), respectively. These results showed that the complex had drug potency against some diseases related to using metabolic enzymes.en_US
dc.description.sponsorshipDokuz Eylul University (University Research Grant) [2010.KB.FEN.13]en_US
dc.description.sponsorshipThe authors thank the Inonu University Faculty of Science Department of Chemistry for the characterization of compounds and Inonu University Technology Center for the elemental analyses of the complex. The authors also acknowledge Dokuz Eylul University for the use of the Oxford Rigaku Xcalibur Eos Di ffractometer (purchased under University Research Grant No: 2010.KB.FEN.13).en_US
dc.identifier.doi10.3390/cryst10030171
dc.identifier.issn2073-4352
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85081269624en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.3390/cryst10030171
dc.identifier.urihttps://hdl.handle.net/11616/99215
dc.identifier.volume10en_US
dc.identifier.wosWOS:000523512100093en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherMdpien_US
dc.relation.ispartofCrystalsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectN-heterocyclic carbeneen_US
dc.subjectcrystal structureen_US
dc.subjectenzyme inhibitionen_US
dc.subjectcarbonic anhydraseen_US
dc.subjectalpha-glycosidaseen_US
dc.titleA Novel Ag-N-Heterocyclic Carbene Complex Bearing the Hydroxyethyl Ligand: Synthesis, Characterization, Crystal and Spectral Structures and Bioactivity Propertiesen_US
dc.typeArticleen_US

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