Effect of Helicobacter pylori eradication on peptic ulcer disease complicated with outlet obstruction

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dc.authoridHilmioğlu, Fatih/0000-0002-6440-5686;
dc.authorwosidHilmioğlu, Fatih/AAJ-4437-2021
dc.authorwosidGurer, Inanc Elif/C-3042-2016
dc.contributor.authorTaskin, V
dc.contributor.authorGurer, I
dc.contributor.authorOzyilkan, E
dc.contributor.authorSare, M
dc.contributor.authorHilmioglu, F
dc.date.accessioned2024-08-04T20:12:10Z
dc.date.available2024-08-04T20:12:10Z
dc.date.issued2000
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground. At present, the prevalence of Helicobacter pylori (H. pylori) in complicated peptic ulcer and the effect of H. pylori eradication on complicated peptic ulcer have not been fully established. In this study, we report the prevalence of H. pylori in peptic ulcer patients complicated with gastric outlet obstruction, effectiveness of oral eradication therapy on these patients, and their long-term follow up. Patients and Methods. Ten consecutive patients presenting with clinically and endoscopically significant obstructed peptic ulcers were included in this study. During each endoscopy, seven gastric biopsy specimens were obtained and analyzed for H. pylori colonization. Results. The antral mucosal biopsy specimens were positive for H. pylori in nine patients. H. pylori infection was eradicated and complete ulcer healing was observed in all patients. The mean follow-up period was 14 (7-24) months. One patient had duodenal perforation and underwent surgical intervention following medical treatment, despite the eradication of H. pylori. Ulcer recurrence was noted in two (22.2%) of nine patients, and in one of them the recurrent ulcer was complicated with obstruction (11.1%). The mean time to ulcer recurrence was 17 months (range, 10-24 months). The biopsies and CLOtests were H. pylori negative at the time of ulcer or erosion recurrence in two patients. Conclusion. We suggest that H. pylori eradication may improve the resolution in obstructive ulcer cases with colonization.en_US
dc.identifier.doi10.1046/j.1523-5378.2000.00005.x
dc.identifier.endpage40en_US
dc.identifier.issn1083-4389
dc.identifier.issue1en_US
dc.identifier.pmid10672050en_US
dc.identifier.scopus2-s2.0-0034146635en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage38en_US
dc.identifier.urihttps://doi.org/10.1046/j.1523-5378.2000.00005.x
dc.identifier.urihttps://hdl.handle.net/11616/93260
dc.identifier.volume5en_US
dc.identifier.wosWOS:000085624100006en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBlackwell Science Incen_US
dc.relation.ispartofHelicobacteren_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectEndoscopic Balloon Dilationen_US
dc.subjectInfectionen_US
dc.subjectPreventionen_US
dc.subjectDilatationen_US
dc.subjectStenosisen_US
dc.subjectVagotomyen_US
dc.titleEffect of Helicobacter pylori eradication on peptic ulcer disease complicated with outlet obstructionen_US
dc.typeArticleen_US

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