Factors affecting survival and recurrence in patients with operated non-small cell lung cancer

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dc.contributor.authorGülmez, Ahmet
dc.contributor.authorElkıran, Emin
dc.date.accessioned2024-08-04T19:42:43Z
dc.date.available2024-08-04T19:42:43Z
dc.date.issued2023
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAim: The most serious problem after curative treatment of non-metastatic lung cancer is disease recurrence. This study was designed to detect markers affecting disease recurrence and survival in operated lung cancer patients. Materials and Methods: In this study, the data of 109 patients diagnosed with lung cancer were analyzed retrospectively. Cut-off values for neutrophil-lymphocyte ra- tio (NLR), platelet-lymphocyte ratio (PLR), alkaline phosphatase (ALP), and gamma glutamyl transpeptidase (GGT) were determined by performing ROC Curve analysis. Ac- cording to these cut-off values, the patients were divided into two groups. Based on the cut-off value of the markers, their effects on both overall survival (OS) and disease-free survival (DFS) were examined. Results: In this study, the median OS of the patients was 53.9 months, and the median DFS was 20.6 months. The patients were re-evaluated by targeting the cut-off value of 2.35 for NLR obtained by ROC analysis. Below this value, mOS and mDFS were calculated as 78.2 and 43.2 months, respectively. Above this value, it was determined as 35.6 and 20.6 months, respectively. A similar evaluation was made for the PLR. As a result of the ROC analysis, the cut-off value was determined as 124.7. Below this value, mOS and mDFS were calculated as 72.4 and 36.9 months, respectively. Above this value, it was determined as 41.7 and 21.8 months, respectively. Both results were statistically significant (p<0.05). Conclusion: This study showed that NLR and PLR predict statistical significance for OS and DFS.en_US
dc.identifier.doi10.5455/annalsmedres.2022.12.373
dc.identifier.endpage277en_US
dc.identifier.issn2636-7688
dc.identifier.issue2en_US
dc.identifier.startpage272en_US
dc.identifier.trdizinid1162293en_US
dc.identifier.urihttps://doi.org/10.5455/annalsmedres.2022.12.373
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1162293
dc.identifier.urihttps://hdl.handle.net/11616/88606
dc.identifier.volume30en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofAnnals of Medical Researchen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleFactors affecting survival and recurrence in patients with operated non-small cell lung canceren_US
dc.typeArticleen_US

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