Cellular Uptake and Transcytosis

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dc.authorscopusid57573824800
dc.authorscopusid57573061300
dc.authorscopusid57219467212
dc.authorscopusid56622412200
dc.authorscopusid57189064109
dc.authorscopusid6603195583
dc.contributor.authorBarin G.
dc.contributor.authorGultekin Y.
dc.contributor.authorPezik E.
dc.contributor.authorOzturk N.
dc.contributor.authorKara A.
dc.contributor.authorVural I.
dc.date.accessioned2024-08-04T20:04:02Z
dc.date.available2024-08-04T20:04:02Z
dc.date.issued2021
dc.departmentİnönü Üniversitesien_US
dc.description.abstractNanoparticles are suitable delivery systems for targeting of drugs, and extensive research in the field of nanomedicine is ongoing. Apart from cellular uptake, nanoparticles sometimes have to cross cellular barriers. Understanding the cellular uptake and transcytosis of nanoparticles are crucial for designing efficient nanoparticles. This chapter provides a review of cellular uptake mechanisms and transcytosis of nanoparticles. Also, the effect of the physicochemical characteristics of nanoparticles on their cellular internalization is also discussed. Although nanocarriers sometimes release their payload at the extracellular disease site and the released active ingredient enters the cells by itself to show its effect, another way is to deliver nanoparticles directly into cells, and then the payload is released there and it shows its effect. Electrostatic, van der Waals, and ionic forces between the cell and the nanoparticle and receptor-mediated recognition of opsonins are behind phagocytosis of nanoparticles. © 2022 Jenny Stanford Publishing Pte. Ltd.en_US
dc.identifier.doi10.1201/9781003164739-10
dc.identifier.endpage279en_US
dc.identifier.isbn9781000375268
dc.identifier.isbn9789814877756
dc.identifier.scopus2-s2.0-85128065458en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage247en_US
dc.identifier.urihttps://doi.org/10.1201/9781003164739-10
dc.identifier.urihttps://hdl.handle.net/11616/92309
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTaylor and Francisen_US
dc.relation.ispartofDrug Delivery with Targeted Nanoparticles: In Vitro and in Vivo Evaluation Methodsen_US
dc.relation.publicationcategoryKitap Bölümü - Uluslararasıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject[No Keyword]en_US
dc.titleCellular Uptake and Transcytosisen_US
dc.typeBook Chapteren_US

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