Petroselinum Crispum is Effective in Reducing Stress-Induced Gastric Oxidative Damage

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dc.contributor.authorAkıncı, Ayşin
dc.contributor.authorEşrefoğlu, Mukaddes
dc.contributor.authorTaşlıdere, Elif
dc.contributor.authorAteş, Burhan
dc.date.accessioned2021-11-23T14:50:02Z
dc.date.available2021-11-23T14:50:02Z
dc.date.issued2017
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAbstract: Background: Oxidative stress has been shown to play a principal role in the pathogenesis of stress-induced gastric injury. Parsley (Petroselinum crispum) contains many antioxidants such as flavanoids, carotenoids and ascorbic acid. Aims: In this study, the histopathological and biochemical results of nutrition with a parsley-rich diet in terms of eliminating stress-induced oxidative gastric injury were evaluated. Study Design: Animal experimentation. Methods: Forty male Wistar albino rats were divided into five groups: control, stress, stress + standard diet, stress + parsley-added diet and stress + lansoprazole (LPZ) groups. Subjects were exposed to 72 hours of fasting and later immobilized and exposed to the cold at +4 degrees for 8 hours to create a severe stress condition. Samples from the animals’ stomachs were arranged for microscopic and biochemical examinations. Results: Gastric mucosal injury was obvious in rats exposed to stress. The histopathologic damage score of the stress group (7.00±0.57) was higher than that of the control group (1.50±0.22) (p<0.05). Significant differences in histopathologic damage score were found between the stress and stress + parsley-added diet groups (p<0.05), the stress and stress + standard diet groups (p<0.05), and the stress and stress + LPZ groups (p<0.05). The mean tissue malondialdehyde levels of the stress + parsley-added group and the stress + LPZ group were lower than that of the stress group (p<0.05). Parsley supported the cellular antioxidant system by increasing the mean tissue glutathione level (53.31±9.50) and superoxide dismutase (15.18±1.05) and catalase (16.68±2.29) activities. Conclusion: Oral administration of parsley is effective in reducing stress-induced gastric injury by supporting the cellular antioxidant defence system.en_US
dc.identifier.citationAKINCI A,EŞREFOĞLU M,TAŞLIDERE E,ATEŞ B (2017). Petroselinum Crispum is Effective in Reducing Stress-Induced Gastric Oxidative Damage. Balkan Medical Journal, 34(1), 53 - 59.en_US
dc.identifier.endpage59en_US
dc.identifier.issn2146-3123
dc.identifier.issn2146-3131
dc.identifier.issue1en_US
dc.identifier.pmid28251024en_US
dc.identifier.startpage53en_US
dc.identifier.trdizinid240491en_US
dc.identifier.urihttps://hdl.handle.net/11616/43315
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/240491
dc.identifier.volume34en_US
dc.identifier.wosWOS:000396361900008en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofBalkan Medical Journalen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titlePetroselinum Crispum is Effective in Reducing Stress-Induced Gastric Oxidative Damageen_US
dc.typeArticleen_US

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