Comparison of patients with hepatitis B virus-associated hepatocellular carcinoma: Data from two hospitals from Turkey and China

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dc.authorscopusid57217614267
dc.authorscopusid57218610706
dc.authorscopusid36666519800
dc.authorscopusid7102264810
dc.authorscopusid35239218400
dc.authorscopusid57189521626
dc.authorscopusid56046535600
dc.contributor.authorCarr B.I.
dc.contributor.authorRui F.
dc.contributor.authorInce V.
dc.contributor.authorYilmaz S.
dc.contributor.authorZhao X.
dc.contributor.authorFeng Y.
dc.contributor.authorLi J.
dc.date.accessioned2024-08-04T20:03:48Z
dc.date.available2024-08-04T20:03:48Z
dc.date.issued2023
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAims: There are many studies on the incidence of hepatitis B virus (HBV)-associated hepatocellular carcinoma (HCC), but very little is known about the HCC features in different populations. The study aimed to compare characteristics in two cohorts of patients with HBV-associated hepatocellular carcinoma from Turkey and China. Methods: Data on patients with HBV-associated HCC diagnosed by imaging or liver biopsy were retrospectively collected from Shandong Provincial Hospital (n = 578) and Inonu University Hospital (n = 359) between January 2002 and December 2020, and the liver function and HCC characteristics were compared. Continuous variables were compared using Student's t-test or Mann–Whitney U test and categorical variables were compared using the ?² test or Fisher's exact test. Results: The patients in the Turkish cohort had significantly worse Child-Pugh scores (Child-Pugh A: 38.3% vs. 87.9%; Child-Pugh B: 40.3% vs. 11.1%; Child-Pugh C: 21.4% vs. 1.0%; p < 0.001) and significantly higher levels of aspartate aminotransferase (66.5 [38.0?126.0] vs. 36.0 [27.0?50.0] IU/L; p < 0.001), alanine aminotransferase (47.5 [30.0?87.3] vs. 33.0 [24.0?45.0] IU/L; p < 0.001), total bilirubin (20.8 [13.7?39.3] vs. 17.9 [13.8?24.0] mg/dL; p < 0.001), and lower albumin levels (32.0 [26.0?39.0] vs. 40.0 [36.1?43.8] g/L; p < 0.001) than patients in Chinese cohort. The tumor characteristics showed the Barcelona Clinic Liver Cancer (BCLC) score (BCLC 1: 5.1% vs. 71.8%; BCLC 2: 48.7% vs. 24.4%; BCLC 3: 24.4% vs. 3.8%; BCLC 4: 21.8% vs. 0; all p < 0.001), maximum tumor diameter (5.0 [3.0?9.0] vs. 3.5 [2.5?6.0] cm; p < 0.001), alpha-fetoprotein values (27.7 vs. 13.2 ng/mL; p < 0.001), and percentage of patients with portal vein tumor thrombus (33% vs. 6.1%; p < 0.001) were all significantly worse in the Turkish cohort compared with Chinese cohort. Conclusions: HBV-associated HCC from the Turkish cohort had worse liver function and more aggressive clinical characteristics than patients from the Chinese cohort. © 2023 The Authors. Portal Hypertension & Cirrhosis published by John Wiley & Sons Ltd on behalf of Chinese Medical Association.en_US
dc.description.sponsorshipNational Institutes of Health, NIH: CA 82723; National Natural Science Foundation of China, NSFC: 81970545, 82170609; Natural Science Foundation of Jiangsu Province: BK20231118; Natural Science Foundation of Shandong Province: ZR2020KH006; Medical Science and Technology Development Foundation, Nanjing Municipality Health Bureau: YKK20058en_US
dc.description.sponsorshipWe would like to thank Inonu University, Malatya and Shandong Provincial Hospital Affiliated to Shandong University for data support. This work was supported in part by NIH grant CA 82723 (Brian I. Carr). Dr. Jie Li wishes to acknowledge the support from the National Natural Science Fund (Nos. 81970545, 82170609), the Natural Science Foundation of Shandong Province (Major Project) (No. ZR2020KH006), the Nanjing Medical Science and Technique Development Foundation (No. YKK20058), and Natural Science Foundation of Jiangsu Province (No. BK20231118).en_US
dc.identifier.doi10.1002/poh2.60
dc.identifier.issn2770-5838
dc.identifier.scopus2-s2.0-85179949595en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.urihttps://doi.org/10.1002/poh2.60
dc.identifier.urihttps://hdl.handle.net/11616/92104
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherJohn Wiley and Sons Incen_US
dc.relation.ispartofPortal Hypertension and Cirrhosisen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectChinaen_US
dc.subjectHepatocellular Carcinomaen_US
dc.subjectTurkeyen_US
dc.titleComparison of patients with hepatitis B virus-associated hepatocellular carcinoma: Data from two hospitals from Turkey and Chinaen_US
dc.typeArticleen_US

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