Does body mass index affect stem cell yield in healthy donors?

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dc.contributor.authorYilmaz, Seda
dc.contributor.authorOkumus, Nazik
dc.contributor.authorSeyhan, Mert
dc.contributor.authorSahin, Rasim
dc.contributor.authorKorkmaz, Gulten
dc.contributor.authorErkurt, Mehmet Ali
dc.contributor.authorNamdaroglu, Sinem
dc.date.accessioned2026-04-04T13:34:47Z
dc.date.available2026-04-04T13:34:47Z
dc.date.issued2025
dc.departmentİnönü Üniversitesi
dc.description.abstractObjectives: Hematopoietic stem cell transplantation is an important treatment for many benign and malignant diseases. Factors affecting the donor response to mobilization and thus hematopoietic progenitor cell yield have been investigated, but studies on donor body mass index are limited and contradictory. Our aim in our study was to investigate this situation. Material and methods: The data of a total of 665 healthy donors were analyzed and divided into 2 groups as body mass index (BMI) < 25 (group 1, n: 247) and >= 25 kg/m(2) (group 2, n: 418). In addition to demographic data, smoking, blood group, agent used for mobilization, number of days of apheresis, volume of blood processed, amount of product collected, complete blood count before mobilization and biochemical parameters were evaluated. Results: Group 1 consisted of 247 and group 2 consisted of 418 participants. Median age was 29 (18-66) years in group 1 and 37 (18-68) years in group 2. Median BMI was 22.49 (16.10-24.98) and 28.06 (25.00-48.27) kg/m(2), respectively. Male donors constituted 62.7 % in group 1 and 73.9 % in group 2. In group 2, the number of apheresis days was lower and the median CD34(+) stem cell count on the first day and in total was statistically significantly higher (7.1 x10(6)/kg and 7.58 x10(6)/kg, respectively). Conclusion: In healthy donors, CD34(+) stem cells were correlated with BMI, whereas no statistically significant difference was found between the groups in terms of smoking habit, blood group, granulocyte stimulating agent type, processed blood volume, non-lymphocyte and biochemical parameters other than LDH.
dc.identifier.doi10.1016/j.transci.2025.104181
dc.identifier.issn1473-0502
dc.identifier.issn1878-1683
dc.identifier.issue4
dc.identifier.orcid0000-0002-3285-417X
dc.identifier.orcid0000-0003-1277-5105
dc.identifier.orcid0000-0002-7222-499X
dc.identifier.orcid0000-0003-1381-4188
dc.identifier.orcid0000-0001-5083-6306
dc.identifier.pmid40609366
dc.identifier.scopus2-s2.0-105009514268
dc.identifier.scopusqualityQ3
dc.identifier.urihttps://doi.org/10.1016/j.transci.2025.104181
dc.identifier.urihttps://hdl.handle.net/11616/109404
dc.identifier.volume64
dc.identifier.wosWOS:001526892100001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherPergamon-Elsevier Science Ltd
dc.relation.ispartofTransfusion and Apheresis Science
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250329
dc.subjectBody mass index
dc.subjectHematopoietic stem cell transplantation
dc.subjectStem cell yield
dc.subjectHealthy donors
dc.titleDoes body mass index affect stem cell yield in healthy donors?
dc.typeArticle

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