Protective effect of polyunsaturated phosphatidylcholine on liver damage induced by biliary obstruction in rats

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dc.authorwosidGürbüz, Necla/H-8965-2018
dc.authorwosidKARAMAN, Abdurrahman/G-7825-2016
dc.contributor.authorKaraman, A
dc.contributor.authorDemirbilek, S
dc.contributor.authorSezgin, N
dc.contributor.authorGürbüz, N
dc.contributor.authorGürses, I
dc.date.accessioned2024-08-04T20:13:27Z
dc.date.available2024-08-04T20:13:27Z
dc.date.issued2003
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground/Purpose: Persistent inflammatory response secondary to congenital or acquired biliary choleastasis plays an important role in the pathophysiology of hepatic tissue damage. The polyunsaturated fatty acids (PUFA) have been shown to suppress the inflammatory reactions in vivo and in vitro. PUFA has been shown also to protect againts various types of experimental liver damage in animal models and isolated hepatocytes. Therefore, the aim of this study was to investigate the protective effect of PUFA administration on liver damage using the rat chronic biliary obstruction model. Methods: Swiss albino rats of either sex were divided into 4 groups as follows: control group (group 1, 10 rats); rats with sham operation and treated with saline group 2, 10 rats); rats with biliary obstruction (group 3, 15 rats); and polyunsaturated phophatidylcholine (PPC)-treated rats with biliary obstruction (Group 4, 15 rats). Biliary obstruction was induced by double ligation and division of the common bile duct. PUFA treatment was started 2 weeks later from biliary obstruction in doses of 50 mg/d per rat and continued for 2 weeks. All animals were killed after 4 weeks of common bile duct ligation or sham operation. Liver damage and cholestasis were determined by biochemical and histologic examinations. Results: The data showed a decrease in plasma bilirubin level (both conjugated and unconjugated) and liver enzyme levels (AST, ALT, AP, GGT, 5'-NT) in group 4, when compared with group 3 (P < .05). Tissue levels of malondialdehyde (MDA) in group 4 was 20.00 +/- 2.93 compared with that in group 3, 27.12 +/- 2.96 (P < .05). Administration of PUFA to the biliary obstructed rats resulted in inhibition of collagen accumulation (P < .05) and ductal proliferation (P < .05). Conclusions: PUFA reduced liver damage, ductular proliferation, and fibrosis in biliary obstructed rats. These effects suggest that it might be a useful agent to preserve liver function in patients with biliary obstruction such as biliary atresia. (C) 2003 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/S0022-3468(03)00393-2
dc.identifier.endpage1347en_US
dc.identifier.issn0022-3468
dc.identifier.issn1531-5037
dc.identifier.issue9en_US
dc.identifier.pmid14523817en_US
dc.identifier.scopus2-s2.0-0141454078en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1341en_US
dc.identifier.urihttps://doi.org/10.1016/S0022-3468(03)00393-2
dc.identifier.urihttps://hdl.handle.net/11616/93613
dc.identifier.volume38en_US
dc.identifier.wosWOS:000185741600013en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherW B Saunders Co-Elsevier Incen_US
dc.relation.ispartofJournal of Pediatric Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectbiliary obstructionen_US
dc.subjectcholestasisen_US
dc.subjectliver damageen_US
dc.subjectpolyunsaturated phosphatidycholineen_US
dc.titleProtective effect of polyunsaturated phosphatidylcholine on liver damage induced by biliary obstruction in ratsen_US
dc.typeArticleen_US

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