Effects of Chronic Light/Dark Cycle on Iron Zinc and Copper Levels in Different Brain Regions of Rats

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dc.contributor.authorKarakoc, Yunus
dc.contributor.authorBuruk, Mehmet Seyfi
dc.contributor.authorAktan, Burak
dc.contributor.authorKirvar, Ramazan
dc.contributor.authorErdogan, Songul
dc.contributor.authorSahbaz, Mehmet Akif
dc.contributor.authorAksoy, Sevket
dc.date.accessioned2024-08-04T20:35:41Z
dc.date.available2024-08-04T20:35:41Z
dc.date.issued2011
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIn this study, we aimed to investigate whether chronic shift in light/dark cycle alters brain trace element concentrations. For this purpose, 20 male Wistar albino adult rats were weighed and randomly divided into three groups. The first group (n = 6) was the control and had been subjected to 12/12-h light/dark cycle for 30 days. The second group (n = 7) was subjected to 6/18-h light/dark cycle for 15 days, and the third group (n = 7) was also subjected to 6/18-h light/dark cycle for 15 days and then returned to normal 12/12-h light/dark cycle for 15 days. When light/dark cycle protocols were completed, tissue specimens of the frontal lobe, temporal lobe, and brain stem were collected. Iron (Fe), zinc (Zn), and copper (Cu) concentrations of the frontal lobe, temporal lobe, and brain stem were determined by an atomic absorption spectrophotometer. When compared with controls, Fe levels of the temporal lobe significantly increased in 6/18-h light/dark cycle group (p < 0.05), whereas it was statistically unchanged in rats which were exposed to 6/18-h light/dark cycle then returned to the normal 12/12-h light/dark cycle period. Our results show that chronic shift in light/dark cycle affects trace element concentrations of the brain, especially Fe level in the temporal lobe, and these changes are reversible.en_US
dc.description.sponsorshipInonu University Scientific Research Foundationen_US
dc.description.sponsorshipThis study was supported by Inonu University Scientific Research Foundation.en_US
dc.identifier.doi10.1007/s12011-011-9081-2
dc.identifier.endpage1007en_US
dc.identifier.issn0163-4984
dc.identifier.issue1-3en_US
dc.identifier.pmid21607704en_US
dc.identifier.scopus2-s2.0-84155168056en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage1003en_US
dc.identifier.urihttps://doi.org/10.1007/s12011-011-9081-2
dc.identifier.urihttps://hdl.handle.net/11616/95515
dc.identifier.volume144en_US
dc.identifier.wosWOS:000298192900097en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherHumana Press Incen_US
dc.relation.ispartofBiological Trace Element Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectTrace elementsen_US
dc.subjectBrainen_US
dc.subjectCircadian rhythmen_US
dc.subjectLight/dark cycleen_US
dc.titleEffects of Chronic Light/Dark Cycle on Iron Zinc and Copper Levels in Different Brain Regions of Ratsen_US
dc.typeArticleen_US

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