Effects of Low- and High-Dose Valproic Acid and Lamotrigine on the Heart in Female Rats

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dc.authoridYildiz, Azibe/0000-0001-5686-7867
dc.authoridVardı, Nigar/0000-0003-0576-1696
dc.authoridParlakpınar, Hakan/0000-0001-9497-3468
dc.authoridAteş, Burhan/0000-0001-6080-229X
dc.authoridParlakpinar, Hakan/0000-0001-9497-3468
dc.authorwosidYildiz, Azibe/ABI-7998-2020
dc.authorwosidVardı, Nigar/C-9549-2018
dc.authorwosidParlakpınar, Hakan/T-6517-2018
dc.authorwosidAteş, Burhan/AAA-3730-2021
dc.authorwosidParlakpinar, Hakan/V-6637-2019
dc.contributor.authorYildiz, Azibe
dc.contributor.authorVardi, Nigar
dc.contributor.authorParlakpinar, Hakan
dc.contributor.authorAtes, Burhan
dc.contributor.authorColakoglu, Neriman
dc.date.accessioned2024-08-04T20:51:36Z
dc.date.available2024-08-04T20:51:36Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractEpilepsy is a chronic neurological disease that affects more than 50 million people worldwide. Antiepileptic drugs (AEDs) are the mainstay of treatment for most patients with epilepsy. However, AEDs have been reported to be associated with adverse cardiac effects. In this study, it was aimed to investigate the possible cardiac effects of low-dose (LD) and high-dose (HD) treatment of valproic acid (VPA) and lamotrigine (LTG), which are commonly used AEDs, in rats without epilepsy. Rats were randomly grouped as control, LD-VPA, HD-VPA, LD-LTG, and HD-LTG. The cardiac effects of AEDs were evaluated using immunohistological, biochemical, and hemodynamic parameters. A dose-dependent increase in the intensity of caspase-3 staining was detected in the VPA and LTG groups. The intensity of connexin-43 and troponin-T staining in the VPA groups and desmin staining in the LTG groups was significantly reduced. Biochemically, HD-VPA and HD-LTG administrations caused a significant increase in MDA level in myocardial tissue. In addition, as a result of hemodynamic evaluations, cardiac functions were found to be affected and blood pressure increased in HD-LTG group. The results of present study support that VPA and LTG treatment can increase cardiac risk markers.en_US
dc.identifier.doi10.1007/s12012-021-09714-6
dc.identifier.endpage340en_US
dc.identifier.issn1530-7905
dc.identifier.issn1559-0259
dc.identifier.issue4en_US
dc.identifier.pmid35064532en_US
dc.identifier.scopus2-s2.0-85123236860en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage326en_US
dc.identifier.urihttps://doi.org/10.1007/s12012-021-09714-6
dc.identifier.urihttps://hdl.handle.net/11616/100423
dc.identifier.volume22en_US
dc.identifier.wosWOS:000745382800001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherHumana Press Incen_US
dc.relation.ispartofCardiovascular Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntiepileptic drugen_US
dc.subjectCardiotoxicityen_US
dc.subjectLamotrigineen_US
dc.subjectMyocardiumen_US
dc.subjectValproic aciden_US
dc.titleEffects of Low- and High-Dose Valproic Acid and Lamotrigine on the Heart in Female Ratsen_US
dc.typeArticleen_US

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