Comparison of blood platelet distribution width and neutrophil-lymphocyte ratio in patients with different grades of knee osteoarthritis

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dc.authoridBüyükavcı, Raikan Soydemir/0000-0002-2234-7158
dc.authoridAkturk, SEMRA/0000-0001-9960-6851;
dc.authorwosidBüyükavcı, Raikan Soydemir/Q-5336-2018
dc.authorwosidAkturk, SEMRA/KTH-9105-2024
dc.authorwosidAKTÜRK, SEMRA/ABI-2757-2020
dc.contributor.authorBuyukavci, Raikan
dc.contributor.authorAkturk, Semra
dc.contributor.authorSag, Sinem
dc.date.accessioned2024-08-04T20:45:35Z
dc.date.available2024-08-04T20:45:35Z
dc.date.issued2018
dc.departmentİnönü Üniversitesien_US
dc.description.abstractOBJECTIVE: The aim of this study was to compare platelet distribution width (PDW) and neutrophil to lymphocyte ratio (NLR) values in mild-to-moderate and severe knee osteoarthritis (OA). METHODS: This was a retrospective study of patients with knee OA according to the Kellgren-Lawrence (KL) grading system. Of 465 patients, 231 were excluded (62 due to not meeting the inclusion criteria and 169 due to the lack of simultaneous haemogram and radiographic evaluations). Demographic characteristics and PDW and NLR values were recorded. The patients were then divided into two groups: KL grade 1-3 (mild-to-moderate OA) and KL grade 4 (severe OA). RESULTS: In severe knee OA patients, blood PDW (13.44 +/- 2.58, p = 0.01) and NLR values (2.16 +/- 0.84, p = 0.04) were elevated as compared with those in mild-to-moderate knee OA patients. Blood PDW and NLR values of >= 12.5 and >= 2.1, respectively, were taken as cut-offs based on a receiver operating characteristics (ROC) curve analysis. In the ROC curve analysis, blood NLR >= 2.1 had 60% sensitivity and 64.8% specificity, and PDW >= 12.5 had 61% sensitivity and 58% specificity in predicting severe knee OA. In a univariate analysis, age (p < 0.001), PDW >= 12.5 (p = 0.029) and blood NLR >= 2.1 (p = 0.030) emerged as significant predictors of the severe knee OA. CONCLUSION: The results suggested that the blood PDW and NLR are novel inflammatory markers that can predict the radiographic severity of knee OA in clinical practice.en_US
dc.identifier.doi10.3233/BMR-171028
dc.identifier.endpage1039en_US
dc.identifier.issn1053-8127
dc.identifier.issn1878-6324
dc.identifier.issue6en_US
dc.identifier.pmid30347592en_US
dc.identifier.scopus2-s2.0-85058295872en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1035en_US
dc.identifier.urihttps://doi.org/10.3233/BMR-171028
dc.identifier.urihttps://hdl.handle.net/11616/98571
dc.identifier.volume31en_US
dc.identifier.wosWOS:000460934000004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherIos Pressen_US
dc.relation.ispartofJournal of Back and Musculoskeletal Rehabilitationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectKnee osteoarthritisen_US
dc.subjectplatelet distribution widthen_US
dc.subjectneutrophil to lymphocyte ratioen_US
dc.subjectinflammatory markeren_US
dc.titleComparison of blood platelet distribution width and neutrophil-lymphocyte ratio in patients with different grades of knee osteoarthritisen_US
dc.typeArticleen_US

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