Investigation of some changes and clonal relationship in enterococci isolates due to relocation of a hospital

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dc.authorscopusid6506868589
dc.authorscopusid55486071600
dc.authorscopusid55469271600
dc.authorscopusid57194141784
dc.authorscopusid56263290900
dc.authorscopusid57214794752
dc.contributor.authorKorkoca H.
dc.contributor.authorHazirolan G.
dc.contributor.authorCicek C.
dc.contributor.authorSavas S.
dc.contributor.authorAkgul O.
dc.contributor.authorTanriverdi E.S.
dc.date.accessioned2024-08-04T19:59:12Z
dc.date.available2024-08-04T19:59:12Z
dc.date.issued2024
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: To investigate the isolation rates, antimicrobial resistance rates, minimum inhibitory concentration values of antimicrobial agents, and clonal relationships of Enterococcus faecalis and Enterococcus faeciumdue to the relocation of a hospital to a newly constructed building. Method: The comparative, prospective study was conducted at adult general intensive care units of the Mus State Hospital, Mus, Turkey, in two phases; before the relocation from January 25 to December 1, 2014, and after the relocation from February 10 to May 24, 2015. Rectal swab samples were collected 72 hours post-hospitalisation. Identification of Enterococcus faecalis and Enterococcus faeciumisolates was determined by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry, and antimicrobial resistance with minimum inhibitory concentration values was detected with Vitek 2 system. The clonal relatedness among the strains was investigated by pulsed-field gel electrophoresis. Data was analysed using SPSS 23. Results: Of the 69 patients, 37(53.62%) were related to pre-relocation phase; 20(54.1%) females and 17(45.9%) males with mean age 62.81±21.71 years. There were 32(46.37%) patients in the post-relocation phase; 13(40.6%) females and 19(59.4%) males with mean age 62.69±21.35 years (p>0.05). Of the 84 enterococci strains isolated, 51(60.7%) were Enterococcus faecium; 28(55%) before relocation and 23(45%) after relocation (p=0.77). The remaining 33(39.3%) isolates were Enterococcus faecalis; 16(48.5%) before relocation and 17(51.5%) after relocation (p=0.73). Multiple strains were located in 7(18.9%) patients before relocation and in 7(21.9%) after relocation. In 1(3.1%) patient after relocation, 2(8.7%) Enterococcus faecium isolates with different resistance and pulsed-field gel electrophoresis patterns were detected. There were no significant differences between the isolation and antibiotic resistance rates before and after relocation (p>0.05), and a clonal relation between the isolates was not detected (p>0.05). Decreased minimum inhibitory concentration values were noted for some antibiotics. Conclusion: Clonal relationship between the isolates and change in the rates of isolation and antimicrobial resistance of Enterococcus faecalis and Enterococcus faecium was not detected due to relocation. Minimum inhibitory concentration values could be used to reveal relocation-related changes in isolates obtained from patients hospitalised in intensive care units. © 2024 Pakistan Medical Association. All rights reserved.en_US
dc.description.sponsorshipMuş Alparslan Üniversitesien_US
dc.description.sponsorshipAcknowledgment: We are grateful to the Unit of Scientific Research Projects, Mus Alparslan University, for financial support.en_US
dc.identifier.doi10.47391/JPMA.8688
dc.identifier.endpage475en_US
dc.identifier.issn0030-9982
dc.identifier.issue4en_US
dc.identifier.pmid38591280en_US
dc.identifier.scopus2-s2.0-85186901761en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage469en_US
dc.identifier.urihttps://doi.org/10.47391/JPMA.8688
dc.identifier.urihttps://hdl.handle.net/11616/90451
dc.identifier.volume74en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPakistan Medical Associationen_US
dc.relation.ispartofJournal of the Pakistan Medical Associationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAntimicrobial drug resistanceen_US
dc.subjectEnterococcusen_US
dc.subjectHospital movingen_US
dc.subjectTransmissionen_US
dc.titleInvestigation of some changes and clonal relationship in enterococci isolates due to relocation of a hospitalen_US
dc.typeArticleen_US

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